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Details

Stereochemistry UNKNOWN
Molecular Formula C12H14N2O3
Molecular Weight 234.2512
Optical Activity ( - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIPROQUALONE, (-)-

SMILES

CC1=NC2=CC=CC=C2C(=O)N1CC(O)CO

InChI

InChIKey=NTGLQWGMESPVBV-UHFFFAOYSA-N
InChI=1S/C12H14N2O3/c1-8-13-11-5-3-2-4-10(11)12(17)14(8)6-9(16)7-15/h2-5,9,15-16H,6-7H2,1H3

HIDE SMILES / InChI

Molecular Formula C12H14N2O3
Molecular Weight 234.2512
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Diproqualone was used primarily for the treatment of inflammatory pain associated with osteoarthritis. The analgesic activity of diproqualoneis synergistic with that of noramidopyrine. It also display anti-inflammatory action in the rat, inhibiting plantar edema with dextran or serotonin, atopic edema from ovalbumin, etc. It has spasmolytic, anticholinergic and antihistaminic action in higher doses. It is not hypnotic and has no anticonvulsant effects. The therapeutic symptoms for diproqualone are all types of pain: postoperative, posttraumatic, dental, neuritis, anti-inflammatory arthritis, etc.

Approval Year

PubMed

PubMed

TitleDatePubMed
Synthesis of new 2,3-dihydroquinazolin-4(1H)-one derivatives for analgesic and anti-inflammatory evaluation.
2010 May
Substance Class Chemical
Created
by admin
on Sat Dec 16 11:12:25 GMT 2023
Edited
by admin
on Sat Dec 16 11:12:25 GMT 2023
Record UNII
52GGM7X5IG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIPROQUALONE, (-)-
Common Name English
4(3H)-QUINAZOLINONE, 3-(2,3-DIHYDROXYPROPYL)-2-METHYL-, (-)-
Systematic Name English
Code System Code Type Description
PUBCHEM
64112
Created by admin on Sat Dec 16 11:12:25 GMT 2023 , Edited by admin on Sat Dec 16 11:12:25 GMT 2023
PRIMARY
FDA UNII
52GGM7X5IG
Created by admin on Sat Dec 16 11:12:25 GMT 2023 , Edited by admin on Sat Dec 16 11:12:25 GMT 2023
PRIMARY