Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C19H22N6S.ClH |
| Molecular Weight | 402.944 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.S=C(N\N=C1/CCCC2=C1N=CC=C2)N3CCN(CC3)C4=CC=CC=N4
InChI
InChIKey=AJEFZRURUAFCRQ-YHLMHSEJSA-N
InChI=1S/C19H22N6S.ClH/c26-19(23-22-16-7-3-5-15-6-4-10-21-18(15)16)25-13-11-24(12-14-25)17-8-1-2-9-20-17;/h1-2,4,6,8-10H,3,5,7,11-14H2,(H,23,26);1H/b22-16+;
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C19H22N6S |
| Molecular Weight | 366.483 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
COTI-2 is an orally available small molecule targeting p53, a tumor suppressor gene that is mutated in over 50% of all cancers. The drug was developed by Clinical Outcome Technologies Inc (now Cotinga Pharmaceuticals) and is believed to act by reactivating mutant p53 and inhibiting the phosphatidylinositol 3-kinase (PI3K)/Akt. The drug is being evaluated in phase I clinical trials for the treatment of gynecologic cancers and head and neck squamous cell carcinoma.
Approval Year
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 10:57:57 GMT 2023
by
admin
on
Sat Dec 16 10:57:57 GMT 2023
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| Record UNII |
52508056ID
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| Record Status |
Validated (UNII)
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| Record Version |
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Created by
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1204956-74-0
Created by
admin on Sat Dec 16 10:57:57 GMT 2023 , Edited by admin on Sat Dec 16 10:57:57 GMT 2023
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52508056ID
Created by
admin on Sat Dec 16 10:57:57 GMT 2023 , Edited by admin on Sat Dec 16 10:57:57 GMT 2023
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PRIMARY |
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