TOLINDATE

US Previously Marketed

Details

Stereochemistry	ACHIRAL
Molecular Formula	C18H19NOS
Molecular Weight	297.415
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C(=S)OC1=CC2=C(CCC2)C=C1)C3=CC=CC(C)=C3

InChI

InChIKey=ANJNOJFLVNXCHT-UHFFFAOYSA-N

InChI=1S/C18H19NOS/c1-13-5-3-8-16(11-13)19(2)18(21)20-17-10-9-14-6-4-7-15(14)12-17/h3,5,8-12H,4,6-7H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C18H19NOS
Molecular Weight	297.415
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: http://www.fda.gov/regulatoryinformation/dockets/ucm129978.htm
Curator's Comment: Description was created using several sources including: https://www.google.com/patents/US3509200; http://www.trademarkia.com/dalnate-72412220.html; http://www.druglead.com/cds/tolindate.html; http://jurbase.ru/postr/docum51/part6.htm

Tolindate, a thiocarbamate, is a synthetic antifungal approved by FDA as an over-the-counter (OTC) drug product and is marketed by Norcliff Thayer Inc. It was prepared by treating 5-indanyl thionochloroformate with N-methyl-m-toluidine and patented in 1970 by USV Pharmaceutical Corporation tas a compound with strong topical antifungal activity that may be administered topically in the form of ointments and solutions. It was used in eastern Europe as Dalnate (USV Pharmaceutical Corporation trademark registerd in 6/26/1973) for topical application in the treatment of various dermatoses. Produced by ZORKA Pharma (at present Hemofarm a.d., Serbia) topical cream or solution Dalnate was registered for marketing in Russia.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Unknown 2596

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L1QTX
Alfa Chemistry	27877-51-6
Alfa Chemistry	ACM27877516
AmicBase - Antimicrobial Activities	6800
Chemieliva Pharmaceutical Co., Ltd	PBCM1258505
ChemMol	99057293	http://www.chemmol.com/chemmol/99057293.html
Compound Cloud	34051
THE BioTek	bt-432684	https://www.thebiotek.com/product/others/bt-432684
ZINC	ZINC000000002190	http://zinc15.docking.org/substances/ZINC000000002190

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Wed Apr 02 09:59:18 GMT 2025` Edited by `admin` on `Wed Apr 02 09:59:18 GMT 2025`
Record UNII	5236RK32KG
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CARBAMOTHIOIC ACID, METHYL(3-METHYLPHENYL)-, O-(2,3-DIHYDRO-1H-INDEN-5-YL) ESTER

Preferred Name

English

TOLINDATE

Official Name

English

tolindate [INN]

Common Name

English

TOLINDATE [USAN]

Common Name

English

TOLINDATE [MI]

Common Name

English

O-5-INDANYL M,N-DIMETHYLTHIOCARBANILATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C514