THEBACON

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H23NO4
Molecular Weight	341.4009
Optical Activity	UNSPECIFIED
Defined Stereocenters	4 / 4
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12OC3=C(OC)C=CC4=C3[C@@]15CCN(C)[C@]([H])(C4)[C@]5([H])CC=C2OC(C)=O

InChI

InChIKey=RRJQTGHQFYTZOW-ILWKUFEGSA-N

InChI=1S/C20H23NO4/c1-11(22)24-16-7-5-13-14-10-12-4-6-15(23-3)18-17(12)20(13,19(16)25-18)8-9-21(14)2/h4,6-7,13-14,19H,5,8-10H2,1-3H3/t13-,14+,19-,20-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C20H23NO4
Molecular Weight	341.4009
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	4 / 4
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://books.google.ru/books?id=PcyoOmjvGzkC&printsec=frontcover&hl=ru#v=onepage&q&f=false
Curator's Comment: Description was created based on several sources, including https://books.google.ru/books?id=szDnBwAAQBAJ&printsec=frontcover&hl=ru#v=onepage&q&f=false | https://www.boehringer-ingelheim.us/history/history-milestone/1885-1948 | https://www.ncbi.nlm.nih.gov/pubmed/23440583

Thebacon (dihydrocodeinone enol acetate, trade name Acedicon) is semisynthetic opioid analgetic and antitussive compound. Boehringer-Ingelheim merketed Acedicon for the treatment of cough. Thebacon is a Schedule I drug, that has not got approved use in US.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Carboxylesterase 2 9 Target ID: CHEMBL3180 Sources: https://www.ncbi.nlm.nih.gov/pubmed/25445008	Substrate 661

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cough 106 Sources: (1963) Progress in Medicinal Chemistry, page 98, retrieved from: https://books.google.ru/books?id=PcyoOmjvGzkC	Primary		Approved 8429	ACEDICON Approved Use Antitussive Launch Date 1928

PubMed

Title	Date	PubMed

Patents

Sample Use Guides

In Vivo Use Guide

7.5-15 mg per day

Route of Administration: Other

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:42:31 GMT 2023` Edited by `admin` on `Fri Dec 15 17:42:31 GMT 2023`
Record UNII	520D430GDK
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

THEBACON

Official Name

English

DIHYDROCODEINONE ENOL ACETATE

Common Name

English

IDS-NT-001

Code

English

thebacon [INN]

Common Name

English

ACETYLDIHYDROCODEINONE

Common Name

English

ACETYLDEMETHYLDIHYDROTHEBAINE

Common Name

English

Thebacon [WHO-DD]

Common Name

English

THEBACON [MI]

Common Name

English

NSC-117860

Code

English

DEA NO. 9315

Common Name

English

MORPHINAN-6-OL, 6,7-DIDEHYDRO-4,5-EPOXY-3-METHOXY-17-METHYL-, 6-ACETATE, (5.ALPHA.)-

Systematic Name

English

Classification Tree Code System Code

WHO-VATC

QR05DA10