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Details

Stereochemistry UNKNOWN
Molecular Formula C11H10ClNO3
Molecular Weight 239.6554
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MESECLAZONE

SMILES

CC1CC2N(C(=O)c3cc(ccc3O2)Cl)O1

InChI

InChIKey=OJGJQQNLRVNIKE-UHFFFAOYSA-N
InChI=1S/C11H10ClNO3/c1-6-4-10-13(16-6)11(14)8-5-7(12)2-3-9(8)15-10/h2-3,5-6,10H,4H2,1H3

HIDE SMILES / InChI

Molecular Formula C11H10ClNO3
Molecular Weight 239.6554
Charge 0
Count
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Meseclazone (W-2395) is a non-steroidal anti-inflammatory drug. It exerts anti-inflammatory, analgesic and antipyretic activity. Meseclazone inhibits in vitro and ex vivo platelet aggregation initiated by the release reaction. It inhibits bradykinin-induced bronchospasm.

Approval Year

PubMed

PubMed

TitleDatePubMed
Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models.
1978
Meseclazone, 5-chlorosalicylic acid and acetylsalicylic acid. Comparison of their effects on in vitro and ex vivo platelet aggregation.
1978 Aug 31
Metabolism of meseclazone in man.
1978 Jan-Feb
Effect of meseclazone and other non-steroidal anti-inflammatory drugs on isolated tracheal chain tone.
1979 Jul 1
Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats.
1980 Mar 15
Antagonism by meseclazone and other nonsteroidal anti-inflammatory drugs of bradykinin-induced bronchospasm.
1982
Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production.
1982 Jul
Substance Class Chemical
Created
by admin
on Sat Jun 26 06:39:09 UTC 2021
Edited
by admin
on Sat Jun 26 06:39:09 UTC 2021
Record UNII
51KFT71THG
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MESECLAZONE
INN   USAN  
USAN   INN  
Official Name English
MESECLAZONE [INN]
Common Name English
NSC-297623
Code English
7-CHLORO-3,3A-DIHYDRO-2-METHYL-2H,9H-ISOXAZOLO(3,2-.BETA.)(1,3)BENZOXAZIN-9-ONE
Common Name English
2H,9H-ISOXAZOLO(3,2-.BETA.)(1,3)BENZOXACIN-9-ONE, 7-CHLORO-3,3A-DIHYDRO-2-METHYL-
Common Name English
MESECLAZONE [USAN]
Common Name English
W-2395
Code English
Classification Tree Code System Code
NCI_THESAURUS C257
Created by admin on Sat Jun 26 06:39:10 UTC 2021 , Edited by admin on Sat Jun 26 06:39:10 UTC 2021
Code System Code Type Description
WIKIPEDIA
Meseclazone
Created by admin on Sat Jun 26 06:39:10 UTC 2021 , Edited by admin on Sat Jun 26 06:39:10 UTC 2021
PRIMARY
INN
4097
Created by admin on Sat Jun 26 06:39:10 UTC 2021 , Edited by admin on Sat Jun 26 06:39:10 UTC 2021
PRIMARY
FDA UNII
51KFT71THG
Created by admin on Sat Jun 26 06:39:10 UTC 2021 , Edited by admin on Sat Jun 26 06:39:10 UTC 2021
PRIMARY
CAS
29053-27-8
Created by admin on Sat Jun 26 06:39:10 UTC 2021 , Edited by admin on Sat Jun 26 06:39:10 UTC 2021
PRIMARY
EVMPD
SUB08783MIG
Created by admin on Sat Jun 26 06:39:10 UTC 2021 , Edited by admin on Sat Jun 26 06:39:10 UTC 2021
PRIMARY
NCI_THESAURUS
C73088
Created by admin on Sat Jun 26 06:39:10 UTC 2021 , Edited by admin on Sat Jun 26 06:39:10 UTC 2021
PRIMARY
ChEMBL
CHEMBL2104738
Created by admin on Sat Jun 26 06:39:10 UTC 2021 , Edited by admin on Sat Jun 26 06:39:10 UTC 2021
PRIMARY
PUBCHEM
34445
Created by admin on Sat Jun 26 06:39:10 UTC 2021 , Edited by admin on Sat Jun 26 06:39:10 UTC 2021
PRIMARY
Related Record Type Details
METABOLITE -> PARENT
MAJOR
Related Record Type Details
ACTIVE MOIETY