MESECLAZONE

Details

Stereochemistry	UNKNOWN
Molecular Formula	C11H10ClNO3
Molecular Weight	239.655
Optical Activity	UNSPECIFIED
Defined Stereocenters	0 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CC1CC2OC3=CC=C(Cl)C=C3C(=O)N2O1

InChI

InChIKey=OJGJQQNLRVNIKE-UHFFFAOYSA-N

InChI=1S/C11H10ClNO3/c1-6-4-10-13(16-6)11(14)8-5-7(12)2-3-9(8)15-10/h2-3,5-6,10H,4H2,1H3

HIDE SMILES / InChI

Molecular Formula	C11H10ClNO3
Molecular Weight	239.655
Charge	0
Count

Stereochemistry	MIXED
Additional Stereochemistry	No
Defined Stereocenters	0 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/4545529 | https://www.ncbi.nlm.nih.gov/pubmed/103240 | https://www.ncbi.nlm.nih.gov/pubmed/6806831

Meseclazone (W-2395) is a non-steroidal anti-inflammatory drug. It exerts anti-inflammatory, analgesic and antipyretic activity. Meseclazone inhibits in vitro and ex vivo platelet aggregation initiated by the release reaction. It inhibits bradykinin-induced bronchospasm.

Approval Year

PubMed

Title	Date	PubMed
Comparative antiphlogistic activity of meseclazone, 5-chlorosalicylic acid, acetylsalicylic acid, phenylbutazone, indomethacin and hydrocortisone in various rat paw edema models.	1978	628674
Meseclazone, 5-chlorosalicylic acid and acetylsalicylic acid. Comparison of their effects on in vitro and ex vivo platelet aggregation.	1978 Aug 31	103240
Metabolism of meseclazone in man.	1978 Jan-Feb	23268
Effect of meseclazone and other non-steroidal anti-inflammatory drugs on isolated tracheal chain tone.	1979 Jul 1	113226
Comparative gastric ulcerogenic effects of meseclazone, 5-chlorosalicylic acid and other nonsteroidal anti-inflammatory drugs following acute and repeated oral administration to rats.	1980 Mar 15	6768168
Antagonism by meseclazone and other nonsteroidal anti-inflammatory drugs of bradykinin-induced bronchospasm.	1982	6806831
Relationship of gastric mucosal damage induced in pigs by antiinflammatory drugs to their effects on prostaglandin production.	1982 Jul	6953009

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:10:30 UTC 2023` Edited by `admin` on `Sat Dec 16 17:10:30 UTC 2023`
Record UNII	51KFT71THG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MESECLAZONE

Official Name

English

meseclazone [INN]

Common Name

English

NSC-297623

Code

English

7-CHLORO-3,3A-DIHYDRO-2-METHYL-2H,9H-ISOXAZOLO(3,2-.BETA.)(1,3)BENZOXAZIN-9-ONE

Common Name

English

2H,9H-ISOXAZOLO(3,2-.BETA.)(1,3)BENZOXACIN-9-ONE, 7-CHLORO-3,3A-DIHYDRO-2-METHYL-

Common Name

English

MESECLAZONE [USAN]

Common Name

English

W-2395

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C257