DEMATIRSEN

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 08:17:38 GMT 2025` Edited by `admin` on `Wed Apr 02 08:17:38 GMT 2025`
Sequence Type	OLIGONUCLEOTIDE
Record UNII	51FM0REX6F
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

dematirsen [INN]

Preferred Name

English

DEMATIRSEN

Official Name

English

RNA, (P-THIO)(GM-UM-UM-GM-M5CM-M5CM-UM-M5CM-M5CM-GM-GM-UM-UM-M5CM-UM-GM-AM-AM-GM-GM-UM-GM-UM-UM-M5CM)

Systematic Name

English

Code System Code Type Description

CAS

1802465-55-9

Created by admin on Wed Apr 02 08:17:38 GMT 2025 , Edited by admin on Wed Apr 02 08:17:38 GMT 2025

PRIMARY

SMS_ID

300000011801

Created by admin on Wed Apr 02 08:17:38 GMT 2025 , Edited by admin on Wed Apr 02 08:17:38 GMT 2025

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NCI_THESAURUS

C166802

Created by admin on Wed Apr 02 08:17:38 GMT 2025 , Edited by admin on Wed Apr 02 08:17:38 GMT 2025

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INN

10486

Created by admin on Wed Apr 02 08:17:38 GMT 2025 , Edited by admin on Wed Apr 02 08:17:38 GMT 2025

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FDA UNII

51FM0REX6F

Created by admin on Wed Apr 02 08:17:38 GMT 2025 , Edited by admin on Wed Apr 02 08:17:38 GMT 2025

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Sugar	Site Range	Site Count
2'-O-Methyl-Ribose	1_1-1_25	25 / 25

Linkage	Site Range	Site Count
Phosporothioate	1_2-1_25	24 / 24

Related Record Type Details


					51FM0REX6F

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_5] [1_6] [1_8] [1_9] [1_13] [1_25]		CYTOSINE		5-METHYLCYTOSINE	6R795CQT4H

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL