COBALTOUS HYDROXIDE

US Approved Allergenic Extract (1994)

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	Co.2HO
Molecular Weight	92.9479
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[OH-].[OH-].[Co++]

InChI

InChIKey=ASKVAEGIVYSGNY-UHFFFAOYSA-L

InChI=1S/Co.2H2O/h;2*1H2/q+2;;/p-2

HIDE SMILES / InChI

Molecular Formula	HO
Molecular Weight	17.0073
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	Co
Molecular Weight	58.9332
Charge	2
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://pubchem.ncbi.nlm.nih.gov/compound/104729ISBN 9780873715980, Foden C.R., Weddell J.L., 'Hazardous Materials: Emergency Action Data' (1991), Retrieved from https://books.google.com/books?id=4IPE8Pjhm8UC&pgISBN: 978-94-010-7024-9, Matar M.S., Mirbach M.J.,Tayim H.A. 'Catalysis in Petrochemical Processes' (1988), p.136, Retrieved from https://books.google.com/books?id=MkD2JnDkZYYC&dqhttp://aygrt.isrj.org/colorArticles/4972.pdfhttp://onlinelibrary.wiley.com/doi/10.1002/3527600418.mb744048e0023/pdfhttps://www.ncbi.nlm.nih.gov/pubmed/27527840https://fscimage.fishersci.com/msds/05330.htmhttp://laboratorychemicals.in/uploads/msds/10026-17-2-49128.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2253206https://monographs.iarc.fr/ENG/Monographs/vol52/mono52-16.pdfhttp://datasheets.scbt.com/sc-227251.pdf
Curator's Comment: description was created based on several sources, including: DOI:10.1080/00958970802416020 | DOI:10.1080/00958972.2010.521553 | https://www.ncbi.nlm.nih.gov/pubmed/7201957 | https://www.ncbi.nlm.nih.gov/pubmed/18475879

Cobaltous iodide is a catalyst used in organic synthesis.

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Hypoxia-inducible factor 1-alpha inhibitor 22 Target ID: Q9NWT6 Gene ID: 55662.0 Gene Symbol: HIF1AN Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/15941769	Inhibitor 8297		1.0 µM [Ki]

Conditions

Condition	Modality	Highest Phase	Product
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Unknown 2578
Anemia 68 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18120180 https://www.ncbi.nlm.nih.gov/pubmed/940922	Primary	Withdrawn	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Erythropoietic effect of cobalt in patients with or without anemia.	1949 May 12	18120180
Cobalt iontophoresis techniques for tracing afferent and efferent connections in the vertebrate CNS.	1975 May 2	1097054
Improved methods for cobalt filling and silver intensification of insect motor neurons.	1982 Jul	7147273
Acute oral toxicity of inorganic cobalt compounds in rats.	1982 Jun	7201957
Inhalation toxicity studies of cobalt sulfate in F344/N rats and B6C3F1 mice.	1990 Aug	2227161
Carcinogenic sulfide salts of nickel and cadmium induce H2O2 formation by human polymorphonuclear leukocytes.	1990 Dec 1	2253206
Synthesis and Anti-Candida Activity of Cobalt(II) Complexes of Benzene-1,2-Dioxyacetic Acid (bdoaH(2)). X-Ray Crystal Structures of [Co(bdoa)(H(2)O)(3)] 3.5H(2)O and {[CO(phen)(3)](bdoa)}(2)24H(2)O (phen = 1,10-Phenanthroline).	1999	18475879
Determination of trace metal ions in common salt by stripping voltammetry.	1999 Nov-Dec	10589495
Cobalt and antimony: genotoxicity and carcinogenicity.	2003 Dec 10	14643417
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway.	2005 Aug	15941769
Synthesis and antifungal potential of Co(II) complexes of 1-(2'-hydroxyphenyl) ethylideneanilines.	2006 Feb	16256249
Expression of surface markers on the human monocytic leukaemia cell line, THP-1, as indicators for the sensitizing potential of chemicals.	2009 Apr	19338585
In vitro assessment of cobalt oxide particle toxicity: identifying and circumventing interference.	2013 Sep	23624240
In vitro evaluation of anticancer and antibacterial activities of cobalt oxide nanoparticles.	2015 Dec	26563952
Purification and characterization of glucose 6-phosphate dehydrogenase enzyme from rainbow trout (Oncorhynchus mykiss) liver and investigation of the effects of some metal ions on enzyme activity.	2015 May	23363574
Differential pulmonary effects of CoO and La2O3 metal oxide nanoparticle responses during aerosolized inhalation in mice.	2016 Aug 15	27527840

Patents

Sample Use Guides

In Vivo Use Guide

For treatment of anemia, oral cobal chloride was administered at doses 25 mg and 50 mg daily.

Route of Administration: Oral

In Vitro Use Guide

HIF asparaginyl hydroxylase activity was measured by a method based on the hydroxylation coupled decarboxylation of 2-oxoglutarate with the synthetic HIF-1α peptides in the presence of varying concentrations of Co (1-5 uM). Ki for HIF asparaginyl hydroxylase was 1uM.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 02:31:16 GMT 2023` Edited by `admin` on `Sat Dec 16 02:31:16 GMT 2023`
Record UNII	51B9AYG60K
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

COBALTOUS HYDROXIDE

Common Name

English

COBALT(II) HYDROXIDE

Systematic Name

English

COBALT HYDROXIDE

Common Name

English

COBALT HYDROXIDE (CO(OH)2)

Common Name

English

COBALT(2+) HYDROXIDE

Systematic Name

English

COBALTOUS HYDROXIDE [MI]

Common Name

English

Code System Code Type Description

WIKIPEDIA

COBALT(II) HYDROXIDE