LAPYRIUM

US Previously Marketed

First approved in 1964

Details

Stereochemistry	ACHIRAL
Molecular Formula	C21H35N2O3
Molecular Weight	363.5142
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	1

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCCCCCCCC(=O)OCCNC(=O)C[N+]1=CC=CC=C1

InChI

InChIKey=UGJWZYARKOFRDB-UHFFFAOYSA-O

InChI=1S/C21H34N2O3/c1-2-3-4-5-6-7-8-9-11-14-21(25)26-18-15-22-20(24)19-23-16-12-10-13-17-23/h10,12-13,16-17H,2-9,11,14-15,18-19H2,1H3/p+1

HIDE SMILES / InChI

Molecular Formula	C21H35N2O3
Molecular Weight	363.5142
Charge	1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/6745010
Curator's Comment: description was created based on several sources, including https://www.drugs.com/international/lapyrium-chloride.html | https://www.ncbi.nlm.nih.gov/pubmed/22426733 | https://www.ncbi.nlm.nih.gov/pubmed/6713839

Lapyrium, or lapirium, as the chloride salt lapirium chloride (INN) or lapyrium chloride (USAN), is a cationic surfactant that is used in cosmetic personal care products as a biocide and antistatic agent. A 50% solution of Lapyrium Chloride produced slight to moderate erythema. Lapyrium is also used in waste-water treatment and corrosion inhibition formulations.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Bacterial infections 234 Sources: Disinfection, Sterilization, and Preservation (1977), p.205, retrieved from: https://books.google.ru/books?id=8EFrAAAAMAAJ	Curative		Withdrawn	VIRAC REX Approved Use Unknown

Sourcing

Vendor/Aggregator	ID	URL
ABI Chem	AC1L2KT2
ABI Chem	AC1Q5PN8
AK Scientific	9475AB
Alfa Chemistry	ACM6272748
BLD Pharm	BD01272406	http://www.bldpharm.com/products/109260-82-4.html
BOC Sciences	6272-74-8
BioSynth	W-104962
BlocksMatrix Scientific	99527
Compound Cloud	22659
Compound Cloud	22660
Hairui	HR133019
NCI Plated 2007	33659
Norris Pharm	NSZB-A026155
Smolecule	S532490	http://www.smolecule.com/products/s532490
THE BioTek	bt-272552	https://www.thebiotek.com/product/inhibitors/bt-272552
Tetrahedron	TS69219
ZINC	ZINC000008214591	http://zinc15.docking.org/substances/ZINC000008214591
eMolecules	44690858

PubMed

Title	Date	PubMed
Scapular reactivity to contact irritants: application-time and area variations.	1984 Apr-Jun	6745010
Intraregional variation between contact irritant patch test sites.	1984 Feb	6713839
Lipases as catalysts in synthesis of fine chemicals.	2012	22426733

Patents

Sample Use Guides

In Vivo Use Guide

Twenty-two diurnally active, fair-skinned, male volunteers were repeatedly patch tested with 10, 15 and 20% lapyrium chloride (LC) for 5 consecutive days.

Route of Administration: Topical

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:26:18 GMT 2023` Edited by `admin` on `Sat Dec 16 01:26:18 GMT 2023`
Record UNII	5172AI8LRR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LAPYRIUM

Common Name

English

LAPYRIUM CATION

Common Name

English

LAPYRIUM ION

Common Name

English

PYRIDINIUM, 1-(2-OXO-2-((2-((1-OXODODECYL)OXY)ETHYL)AMINO)ETHYL)

Common Name

English

Code System Code Type Description

RXCUI

28456