ATIPROSIN MALEATE

Details

Stereochemistry	RACEMIC
Molecular Formula	C20H29N3.C4H4O4
Molecular Weight	427.5365
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C/C(O)=O.[H][C@@]12CCN3C4=CC=CC=C4C(C)=C3[C@@]1([H])N(CC)CCN2C(C)C

InChI

InChIKey=MPSLGGPOYBRWKD-ZKUJQEIMSA-N

InChI=1S/C20H29N3.C4H4O4/c1-5-21-12-13-22(14(2)3)18-10-11-23-17-9-7-6-8-16(17)15(4)19(23)20(18)21;5-3(6)1-2-4(7)8/h6-9,14,18,20H,5,10-13H2,1-4H3;1-2H,(H,5,6)(H,7,8)/b;2-1-/t18-,20+;/m1./s1

HIDE SMILES / InChI

Molecular Formula	C20H29N3
Molecular Weight	311.4644
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2444771

Atiprosin (AY-28,228), an octahydro-pyrazino-pyrido-indole drug, possesses the alpha-adrenoceptor antagonist activity and exerts antihypertensive effects. Atiprosin has never been marketed

Approval Year

PubMed

Title	Date	PubMed
Octahydropyrazino[2',3':3,4]pyrido[1,2-a]indoles. A new class of potent antihypertensive agents.	1987 Feb	3806618
In vitro isolated tissue studies with atiprosin (AY-28,228): a new antihypertensive compound.	1987 Sep	2444771
Antihypertensive and hypotensive actions of atiprosin (AY-28,228) in rats, dogs, and monkeys.	1987 Sep	2444784

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:40:14 GMT 2023` Edited by `admin` on `Fri Dec 15 15:40:14 GMT 2023`
Record UNII	50SZ4782J0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ATIPROSIN MALEATE

Official Name

English

ATIPROSIN MALEATE [USAN]

Common Name

English

PYRAZINO(2',3':3,4)PYRIDO(1,2-A)INDOLE, 1-ETHYL-1,2,3,4,4A,5,6,12B-OCTAHYDRO-12-METHYL-4-(1-METHYLETHYL)-, TRANS, (Z)-2-BUTENEDIOATE (1:1)

Common Name

English

TRANS-1-ETHYL-1,2,3,4,4A,5,6,12B-OCTAHYDRO-4-ISOPROPYL-12-METHYLPYRAZINO(2',3':3,4)PYRIDO(1,2-A)INDOLE MALEATE (1:1)

Common Name

English

AY-28228

Code

English

AY-28,228

Code

English

Classification Tree Code System Code

NCI_THESAURUS

C29713