FOSOPAMINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C9H14NO5P
Molecular Weight	247.1849
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CNCCC1=CC(O)=C(OP(O)(O)=O)C=C1

InChI

InChIKey=WHEGQKBWPSOMHG-UHFFFAOYSA-N

InChI=1S/C9H14NO5P/c1-10-5-4-7-2-3-9(8(11)6-7)15-16(12,13)14/h2-3,6,10-11H,4-5H2,1H3,(H2,12,13,14)

HIDE SMILES / InChI

Molecular Formula	C9H14NO5P
Molecular Weight	247.1849
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2483441 | https://adisinsight.springer.com/drugs/800002585

Fosopamine (also known as Sim 2055), is a prodrug of epinine was studied for the treatment of renal failure and of essential hypertension. However, phase II of clinical trials in Italy was discontinued in 1995. Information about the current development of this drug is not available.

Originator

Approval Year

PubMed

Title	Date	PubMed
Cardiovascular and renal action of dopaminergic prodrugs.	1989	2483441
Development of dopaminergic drugs for the chronic treatment of congestive heart failure.	1990	1983011
Kinetics and pharmacodynamic effects of a novel prodrug of N-methyldopamine at single dose in healthy volunteers.	1993 Jun	8352818

Sample Use Guides

In Vivo Use Guide

SIM2055 (FOSOPAMINE) was administered at increasing doses (from 100 to 300 mg).

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:46:56 UTC 2023` Edited by `admin` on `Fri Dec 15 15:46:56 UTC 2023`
Record UNII	50Q2Q042YR
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FOSOPAMINE

Official Name

English

fosopamine [INN]

Common Name

English

4-(2-(METHYLAMINO)ETHYL)PYROCATECHOL 1-(DIHYDROGEN PHOSPHATE)

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66884