Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C11H8NO4.Na |
| Molecular Weight | 241.1753 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].CC1=C(C)C=C2C(=O)C(C(=O)C2=C1)=[N+]([O-])[O-]
InChI
InChIKey=KGLVEXSGYXXSOJ-UHFFFAOYSA-N
InChI=1S/C11H8NO4.Na/c1-5-3-7-8(4-6(5)2)11(14)9(10(7)13)12(15)16;/h3-4H,1-2H3;/q-1;+1
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C11H8NO4 |
| Molecular Weight | 218.1855 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Sodium nivimedone (BRL10833) is an orally administered anti-allergic agent with similar properties to DSCG. Nivimedone inhibited IgE-mediated passive cutaneous anaphylactic (PCA) reactions in the rat and the antigen-induced release of histamine from human lung passively sensitized with atopic serum. The pharmacological potency of sodium nivimedone when compared to DSCG was 42 times greater in the human lung system and approximately ten times greater in rat PCA. In addition, single doses of sodium nivimedone given by mouth inhibited antigen-induced bronchoconstriction in man.
Approval Year
Sample Use Guides
Sodium nivimedone (BRL10833) given at an oral dose of 200 mg thrice daily, was compared, after a preliminary standardization week, with placebo in a 6-week double-blind cross-over trial.
Route of Administration:
Oral
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:54:31 GMT 2023
by
admin
on
Fri Dec 15 18:54:31 GMT 2023
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| Record UNII |
50HX07BAJU
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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57441-90-4
Created by
admin on Fri Dec 15 18:54:31 GMT 2023 , Edited by admin on Fri Dec 15 18:54:31 GMT 2023
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64752
Created by
admin on Fri Dec 15 18:54:31 GMT 2023 , Edited by admin on Fri Dec 15 18:54:31 GMT 2023
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50HX07BAJU
Created by
admin on Fri Dec 15 18:54:31 GMT 2023 , Edited by admin on Fri Dec 15 18:54:31 GMT 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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SOLVATE->ANHYDROUS |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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ACTIVE MOIETY |
