Details
Stereochemistry | ABSOLUTE |
Molecular Formula | C33H58N6O5 |
Molecular Weight | 618.8508 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCCCCCCCCCCCCCC(=O)OC[C@H](CCOC(=O)[C@@H](N)C(C)C)CN1C=NC2=C1NC(N)=NC2=O
InChI
InChIKey=ACBSZTQIFTYFGH-IAPPQJPRSA-N
InChI=1S/C33H58N6O5/c1-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-27(40)44-23-26(20-21-43-32(42)28(34)25(2)3)22-39-24-36-29-30(39)37-33(35)38-31(29)41/h24-26,28H,4-23,34H2,1-3H3,(H3,35,37,38,41)/t26-,28+/m1/s1
Molecular Formula | C33H58N6O5 |
Molecular Weight | 618.8508 |
Charge | 0 |
Count |
|
Stereochemistry | ABSOLUTE |
Additional Stereochemistry | No |
Defined Stereocenters | 2 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Omaciclovir (previously known as H2G), a cyclic guanosine analog that is structurally similar to acyclovir and was in clinical development for the treatment of herpesvirus infections. This drug acted against varicella-zoster virus (VZV), by the formation of high concentrations of relatively stable H2G-triphosphate, which is a potent inhibitor of the viral DNA polymerases. However, further development of this drug was discontinued.
Originator
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
The antiherpesvirus activity of H2G [(R)-9-[4-hydroxy-2-(hydroxymethyl)butyl]guanine] is markedly enhanced by the novel immunosuppressive agent mycophenolate mofetil. | 1998 Dec |
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Activity of H2G on human herpesvirus-6B strains either sensitive or resistant to ganciclovir. | 2010 Jun |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:48:22 GMT 2023
by
admin
on
Fri Dec 15 15:48:22 GMT 2023
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Record UNII |
506LI1B3A3
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C281
Created by
admin on Fri Dec 15 15:48:22 GMT 2023 , Edited by admin on Fri Dec 15 15:48:22 GMT 2023
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NCI_THESAURUS |
C29575
Created by
admin on Fri Dec 15 15:48:22 GMT 2023 , Edited by admin on Fri Dec 15 15:48:22 GMT 2023
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Code System | Code | Type | Description | ||
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DTXSID00173167
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PRIMARY | |||
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135399823
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506LI1B3A3
Created by
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DB15651
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C152820
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LL-15
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195156-77-5
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CHEMBL2105845
Created by
admin on Fri Dec 15 15:48:22 GMT 2023 , Edited by admin on Fri Dec 15 15:48:22 GMT 2023
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PRIMARY |
Related Record | Type | Details | ||
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ACTIVE MOIETY |