THYMOCTONAN

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2292455 | https://www.ncbi.nlm.nih.gov/pubmed/7908278 | https://www.ncbi.nlm.nih.gov/pubmed/10093035

Thymoctonan (also known as Thymic humoral factor γ2 ) is an octapeptide thymic hormone patented by Yeda Research and Development Co. Ltd. as an immunoregulatory agent. In preclinical models, Thymoctonan exerts potent anti-tumor activity in mice and significantly increases the specific cytotoxic response of immune spleen cells. In addition, Thymoctonan treatment improved the competence of immune spleen cells in adoptive immunotherapy when performed in combination with chemotherapy by melphalan. Besides that Thymoctonan enhancing the anti-viral potential of murine cytomegalovirus immune spleen cells. In fatal murine cytomegalovirus infection model, daily injections of Thymoctonan- enhanced murine cytomegalovirus immune spleen cells prevented the development of a fatal disease in 93% of the recipient mice.

Originator

Approval Year

PubMed

Title	Date	PubMed
THF-gamma 2-mediated reduction of pulmonary metastases and augmentation of immunocompetence in C57BL/6 mice bearing B16-melanoma.	1999-03	10093035

Patents

Substance Class	Protein Created by `admin` on `Mon Mar 31 20:46:45 GMT 2025` Edited by `admin` on `Mon Mar 31 20:46:45 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	5027686086
Record Status	`FAILED`
Record Version

Download

Name

Type

Language

THYMOCTONAN

Official Name

English

thymoctonan [INN]

Preferred Name

English

THYMIC HUMORAL FACTOR .GAMMA.2 (OX)

Common Name

English

THF-GAMMA 2

Common Name

English

THYMIC HUMORAL FACTOR-GAMMA 2

Common Name

English

L-LEUCINE, L-LEUCYL-L-.ALPHA.-GLUTAMYL-L-.ALPHA.-ASPARTYLGLYCYL-L-PROLYL-L-LYSYL-L-PHENYLALANYL-

Common Name

English

LEU-GLU-ASP-GLY-PRO-LYS-PHE-LEU

Common Name

English

(-)-THYMOCTONAN

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C308