PIROHEPTINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C22H25N.ClH
Molecular Weight	339.902
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.CCN1CCC(C1C)=C2C3=CC=CC=C3CCC4=CC=CC=C24

InChI

InChIKey=PLJNHZOEOXGWIR-UHFFFAOYSA-N

InChI=1S/C22H25N.ClH/c1-3-23-15-14-19(16(23)2)22-20-10-6-4-8-17(20)12-13-18-9-5-7-11-21(18)22;/h4-11,16H,3,12-15H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	C22H25N
Molecular Weight	303.4406
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: www.ncbi.nlm.nih.gov/pubmed/2236897 | http://onlinelibrary.wiley.com/doi/10.1002/14356007.a19_001.pub2/full

Piroheptine is an antagonist of muscarinic acetylcholine receptors. The drug was used for the treatment of Parkinson's disease, however, it is no longer marketed.

CNS Activity

Originator

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Muscarinic acetylcholine receptor 162 Target ID: CHEMBL2094109 Sources: www.ncbi.nlm.nih.gov/pubmed/2236897	Antagonist 2849

Conditions

Condition	Modality	Targets	Highest Phase	Product
Parkinson's disease 232 Sources: http://onlinelibrary.wiley.com/doi/10.1002/14356007.a19_001.pub2/full	Primary		Approved 8583	TRIMOL Approved Use Unknown

Doses

Dose	Population	Adverse events
30 mg 1 times / day multiple, oral Dose: 30 mg, 1 times / day Route: oral Route: multiple Dose: 30 mg, 1 times / day Sources: https://link.springer.com/content/pdf/10.1007%2F978-3-319-56015-1_224-1.pdf	unhealthy Health Status: unhealthy Sex: unknown Food Status: UNKNOWN Sources: https://link.springer.com/content/pdf/10.1007%2F978-3-319-56015-1_224-1.pdf	Sources: https://link.springer.com/content/pdf/10.1007%2F978-3-319-56015-1_224-1.pdf

PubMed

Title	Date	PubMed
Effects of anticholinergic antiparkinsonian drugs on binding of muscarinic receptor subtypes in rat brain.	1990-09	2236897
Biperiden and piroheptine do not affect the serum level of zotepine, a new antipsychotic drug.	1990-07	1975759
Suppression of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurotoxicity in mouse brain by piroheptine and trihexyphenidyl.	1988-02	3258627
Pharmacological study of piroheptine, a new antiparkinson drug. II. Anticholinergic, antihistaminic, and psychopharmacological actions and toxicity.	1972-06	4403219
Pharmacological study of piroheptine, a new antiparkinson drug, 3-(10,11-dihydro-5H-dibenzo(a,d)cyclohepten-5-ylidene)-1-ethyl-2-methylpyrrolidine. I. Effects on drug-induced tremor and catatonia, and on adrenergic actions.	1972-06	4626187
Effect of piroheptine, a new antiparkinson drug, on dopamine uptake into synaptosomes from corpus striatum of rat brain.	1972-06	5068358

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 17:57:06 GMT 2025` Edited by `admin` on `Mon Mar 31 17:57:06 GMT 2025`
Record UNII	4ZM573199N
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PIROHEPTINE HYDROCHLORIDE

Common Name

English

TRIMOL

Preferred Name

English

PIROHEPTINE HYDROCHLORIDE [MI]

Common Name

English

PYRROLIDINE, 3-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-ETHYL-2-METHYL-, HYDROCHLORIDE (1:1)

Systematic Name

English

PIROHEPTINE HYDROCHLORIDE [JAN]

Common Name

English

3-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-ETHYL-2-METHYL, HYDROCHLORIDE

Common Name

English

PYRROLIDINE, 3-(10,11-DIHYDRO-5H-DIBENZO(A,D)CYCLOHEPTEN-5-YLIDENE)-1-ETHYL-2-METHYL-, HYDROCHLORIDE

Systematic Name

English

FK-1190

Code

English

Piroheptine hydrochloride [WHO-DD]

Common Name

English

Code System Code Type Description

MERCK INDEX

m8886