Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H7N2O2S.Na |
| Molecular Weight | 194.187 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].NC1=CC=C(C=C1)S([NH-])(=O)=O
InChI
InChIKey=CGRKCGWEOIQFRD-UHFFFAOYSA-N
InChI=1S/C6H7N2O2S.Na/c7-5-1-3-6(4-2-5)11(8,9)10;/h1-4H,7H2,(H-,8,9,10);/q-1;+1
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H8N2O2S |
| Molecular Weight | 172.205 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Originator
Approval Year
Cmax
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
2.08 μg/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/27010464 |
10 mg/kg bw single, oral dose: 10 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
SULFANILAMIDE plasma | Capra hircus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
AUC
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
81.3 μg × h/mL EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/27010464 |
10 mg/kg bw single, oral dose: 10 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
SULFANILAMIDE plasma | Capra hircus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
T1/2
| Value | Dose | Co-administered | Analyte | Population |
|---|---|---|---|---|
3.71 h EXPERIMENT https://www.ncbi.nlm.nih.gov/pubmed/27010464 |
10 mg/kg bw single, oral dose: 10 mg/kg bw route of administration: Oral experiment type: SINGLE co-administered: |
SULFANILAMIDE plasma | Capra hircus population: HEALTHY age: ADULT sex: MALE food status: UNKNOWN |
Doses
| Dose | Population | Adverse events |
|---|---|---|
15 % 1 times / day steady, topical Recommended Dose: 15 %, 1 times / day Route: topical Route: steady Dose: 15 %, 1 times / day Sources: |
unhealthy, adult Health Status: unhealthy Condition: bacterial infection (Candida albicans) Age Group: adult Sex: F Sources: |
Other AEs: Local reaction... Other AEs: Local reaction (0.2%) Sources: |
AEs
| AE | Significance | Dose | Population |
|---|---|---|---|
| Local reaction | 0.2% | 15 % 1 times / day steady, topical Recommended Dose: 15 %, 1 times / day Route: topical Route: steady Dose: 15 %, 1 times / day Sources: |
unhealthy, adult Health Status: unhealthy Condition: bacterial infection (Candida albicans) Age Group: adult Sex: F Sources: |
PubMed
| Title | Date | PubMed |
|---|---|---|
| Should celecoxib be contraindicated in patients who are allergic to sulfonamides? Revisiting the meaning of 'sulfa' allergy. | 2001 |
|
| Use of antibiotics to treat bacteriuria of pregnancy in the Nordic countries. Which antibiotics are appropriate to treat bacteriuria of pregnancy? | 2001 Apr |
|
| Neurology was there in the 1930s. | 2001 Jun |
|
| Characterisation of carbonic anhydrase in Plasmodium falciparum. | 2001 May 15 |
|
| E7070, a novel sulphonamide agent with potent antitumour activity in vitro and in vivo. | 2001 Nov |
|
| Antibiotic resistance in bacteria from magpies (Pica pica) and rabbits (Oryctolagus cuniculus) from west Wales. | 2001 Oct |
|
| Trichinella britovi in domestic pig--a case report. | 2002 |
|
| Molecular epidemiology of cystic fibrosis-linked Burkholderia cepacia complex isolates from three national referral centres in Ireland. | 2002 |
|
| Antimicrobial resistance and plasmid profiles of Campylobacter jejuni and Campylobacter coli from human and animal sources. | 2002 |
|
| Effects of anion and cation inhibitors and carbonic anhydrase inhibitors upon the activity of the gypsy moth (Lepidoptera: Lymantriidae) nucleo-polyhedrovirus. | 2002 Apr |
|
| Sulphonamide residues in eggs following drug administration via the drinking water. | 2002 Apr |
|
| Drug release properties of pectinate microspheres prepared by emulsification method. | 2002 Aug 21 |
|
| Pneumocystis pneumonia. | 2002 Dec |
|
| Test strip for determination of nitrite in water. | 2002 Jul |
|
| Spectrophotometric determination of serum nitrite and nitrate by copper-cadmium alloy. | 2002 Jul 1 |
|
| Improving broad specificity hapten recognition with protein engineering. | 2002 Jul 17 |
|
| Liquid chromatographic-tandem mass spectrometric determination of selected sulphonamides in milk. | 2002 Jun 25 |
|
| Role of carbon dioxide and ion transport in the formation of sub-embryonic fluid by the blastoderm of the Japanese quail. | 2002 Mar |
|
| The sorption and transport of a sulphonamide antibiotic in soil systems. | 2002 May 10 |
|
| Evidence for a membrane site of action for 14,15-EET on expression of aromatase in vascular smooth muscle. | 2002 Nov |
|
| The enhancement of the hyperglycemic effect of S-nitrosoglutathione and S-nitroso-N-acetylpenicillamine by vitamin C in an animal model. | 2002 Sep 13 |
|
| Exposure to receptor-activator of NFkappaB ligand renders pre-osteoclasts resistant to IFN-gamma by inducing terminal differentiation. | 2003 |
|
| Measurement of physiological S-nitrosothiols: a problem child and a challenge. | 2003 Aug |
|
| Risk factors for antibiotic resistance in Campylobacter spp. isolated from raw poultry meat in Switzerland. | 2003 Dec 9 |
|
| Polyelectrolyte Complexes: Interactions between Lignosulfonate and Chitosan. | 2003 Mar-Apr |
|
| Early manifestation of nephropathy in rats with arterial calcinosis. | 2003 May |
|
| Facilitation of addition-elimination reactions in pyrimidines and purines using trifluoroacetic acid in trifluoroethanol. | 2003 Nov 21 |
|
| Investigation of structural and dynamic features of the radicals produced in gamma irradiated sulfanilamide: an ESR study. | 2003 Nov 28 |
|
| Validated HPLC method for the determination of ranitidine in plasma. | 2003 Oct |
|
| High-performance liquid chromatography/inductively coupled plasma mass spectrometry and tandem mass spectrometry for the detection of carbon-containing compounds. | 2004 |
|
| Integron analysis and genetic mapping of antimicrobial resistance genes in Salmonella enterica serotype Typhimurium. | 2004 |
|
| Simultaneous determination of cefatrizine and clavulanic acid in dog plasma by HPLC. | 2004 Apr 1 |
|
| 4-sulphamoylphenyl semicarbazones with anticonvulsant activity. | 2004 Aug |
|
| A new method for purification of carbonic anhydrase isozymes by affinity chromatography. | 2004 Feb |
|
| Carbonic anhydrase inhibitors. Inhibition of mitochondrial isozyme V with aromatic and heterocyclic sulfonamides. | 2004 Feb 26 |
|
| Carbonic anhydrase inhibitors: N-(p-sulfamoylphenyl)-alpha-D-glycopyranosylamines as topically acting antiglaucoma agents in hypertensive rabbits. | 2004 Jan 5 |
|
| Effects of pig slurry on the sorption of sulfonamide antibiotics in soil. | 2004 Jul |
|
| Sorption of sulfonamide pharmaceutical antibiotics on whole soils and particle-size fractions. | 2004 Jul-Aug |
|
| Plasmodium falciparum carbonic anhydrase is a possible target for malaria chemotherapy. | 2004 Jun |
|
| Effects of polymorphic differences for sulfanilamide, as seen through 13C and 15N solid-state NMR, together with shielding calculations. | 2004 Mar |
|
| An experimental animal model of aseptic loosening of hip prostheses in sheep to study early biochemical changes at the interface membrane. | 2004 Mar 3 |
|
| Defective DNA repair as a potential mechanism for the rapid development of drug resistance in Plasmodium falciparum. | 2004 May 4 |
|
| Lessons unlearned. | 2004 May-Jun |
|
| Theoretical study of gas-phase acidity, pKa, lipophilicity, and solubility of some biologically active sulfonamides. | 2004 Oct 15 |
|
| Pharmacokinetics of the nonsteroidal steroid sulphatase inhibitor 667 COUMATE and its sequestration into red blood cells in rats. | 2004 Oct 4 |
|
| Molecular characterization of bifunctional hydroxymethyldihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium falciparum. | 2004 Sep |
Sample Use Guides
One applicatorful (about 6g) intravaginally once or twice daily. Improvements in symptoms should
occur within a few days, but treatment should be continued for a period of 30 days.
Route of Administration:
Vaginal
Antimicrobial activity of sulfanilamide was tested with different bacterial and yeast strains. MIC values were 8 ug/ml for Listeria innocua, Escherishia coli and Pseudomonas aeruginosa; 16 ug/ml for Staphylococcus aureu and Candida albicans; 100 ug/ml for Botrytis cinerea and Fusarium oxysporum culmorum.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:05:45 GMT 2023
by
admin
on
Fri Dec 15 15:05:45 GMT 2023
|
| Record UNII |
4ZB6W6B524
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
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DTXSID00143688
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10103-15-8
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