U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Tue Apr 01 21:41:47 GMT 2025
Edited
by admin
on Tue Apr 01 21:41:47 GMT 2025
Protein Type ENZYME
Protein Sub Type
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
4YV4KW88GD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
AEB-1102
Preferred Name English
PEGZILARGINASE
USAN   INN  
Official Name English
DES-MET1-ARGINASE-1 (LIVER-TYPE ARGINASE, EC 3.5.3.1) (HOMO SAPIENS) FROM WHICH MANGANESE HAS BEEN REPLACED WITH COBALT, AN AVERAGE OF 10 PRIMARY AMINES (OF N-TERMINAL SERINES AND N6-LYSINES) ARE AMIDIFIED WITH (METHOXYPOLY(ETHYLENEOXY))ACETYL, NON-COVAL
Systematic Name English
DES-MET1-ARGINASE-1 (HUMAN) DICOBALT(II) COMPLEX, TRIMER
Common Name English
CO-ARGI-PEG
Common Name English
AEB1102
Code English
Pegzilarginase [WHO-DD]
Common Name English
PEGZILARGINASE [USAN]
Common Name English
POLY(OXY-1,2-ETHANEDIYL), .ALPHA.-(CARBOXYMETHYL)-.OMEGA.-METHOXY-, AMIDE WITH ARGINASE 1 (COBALT COFACTOR) (SYNTHETIC HUMAN) (1:10), TRIMER
Systematic Name English
pegzilarginase [INN]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C29726
Created by admin on Tue Apr 01 21:41:47 GMT 2025 , Edited by admin on Tue Apr 01 21:41:47 GMT 2025
NCI_THESAURUS C274
Created by admin on Tue Apr 01 21:41:47 GMT 2025 , Edited by admin on Tue Apr 01 21:41:47 GMT 2025
FDA ORPHAN DRUG 466614
Created by admin on Tue Apr 01 21:41:47 GMT 2025 , Edited by admin on Tue Apr 01 21:41:47 GMT 2025
Code System Code Type Description
INN
10594
Created by admin on Tue Apr 01 21:41:47 GMT 2025 , Edited by admin on Tue Apr 01 21:41:47 GMT 2025
PRIMARY
NCI_THESAURUS
C125143
Created by admin on Tue Apr 01 21:41:47 GMT 2025 , Edited by admin on Tue Apr 01 21:41:47 GMT 2025
PRIMARY
CAS
1659310-95-8
Created by admin on Tue Apr 01 21:41:47 GMT 2025 , Edited by admin on Tue Apr 01 21:41:47 GMT 2025
PRIMARY
USAN
GH-163
Created by admin on Tue Apr 01 21:41:47 GMT 2025 , Edited by admin on Tue Apr 01 21:41:47 GMT 2025
PRIMARY
DRUG BANK
DB14780
Created by admin on Tue Apr 01 21:41:47 GMT 2025 , Edited by admin on Tue Apr 01 21:41:47 GMT 2025
PRIMARY
SMS_ID
100000177945
Created by admin on Tue Apr 01 21:41:47 GMT 2025 , Edited by admin on Tue Apr 01 21:41:47 GMT 2025
PRIMARY
FDA UNII
4YV4KW88GD
Created by admin on Tue Apr 01 21:41:47 GMT 2025 , Edited by admin on Tue Apr 01 21:41:47 GMT 2025
PRIMARY
Related Record Type Details
PEGZILARGINASE
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
METAL_BINDING Amount: COBALTOUS CATION AI1MR454XG
PEGYLATION [1_1] [2_1] [3_1] N-TERMINUS MPEG 6000 ACETYL SERINE DJ10NUH2XU
PEGYLATION RESIDUE_SPECIFIC Amount: MPEG 6000 ACETYL LYSINE 83L9KWH0UW
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
PRIVACY NOTICE
ACCESSIBILITY
DISCLAIMER
HHS VULNERABILITY DISCLOSURE
For language access assistance, contact the NCATS Public Information Officer
National Center for Advancing Translational Sciences (NCATS),
6701 Democracy Boulevard, Bethesda MD 20892-4874 • 301-594-8966