ABT-724

C(N1CCN(CC1)C2=NC=CC=C2)C3=NC4=CC=CC=C4N3

InChIKey=FRPJGTNLZNXQEX-UHFFFAOYSA-N

InChI=1S/C17H19N5/c1-2-6-15-14(5-1)19-16(20-15)13-21-9-11-22(12-10-21)17-7-3-4-8-18-17/h1-8H,9-13H2,(H,19,20)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Targets

Primary Target	Pharmacology	Condition	Potency
Dopamine D4 receptor 71 Target ID: CHEMBL219 Sources: https://adisinsight.springer.com/drugs/800019657\|https://www.ncbi.nlm.nih.gov/pubmed/15087502	Agonist 2678		12.4 nM [EC50]

PubMed

Title	Date	PubMed
Dopamine D4 ligands and models of receptor activation: 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole and related heteroarylmethylarylpiperazines exhibit a substituent effect responsible for additional efficacy tuning.	2004 Apr 22	15084133
Discovery of 2-(4-pyridin-2-ylpiperazin-1-ylmethyl)-1H-benzimidazole (ABT-724), a dopaminergic agent with a novel mode of action for the potential treatment of erectile dysfunction.	2004 Jul 15	15239663

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 09:44:17 GMT 2023` Edited by `admin` on `Sat Dec 16 09:44:17 GMT 2023`
Record UNII	4WV2575JWT
Record Status	`Validated (UNII)`
Record Version

Name

Type

Language

ABT-724

Common Name

English

1H-BENZIMIDAZOLE, 2-((4-(2-PYRIDINYL)-1-PIPERAZINYL)METHYL)-

Systematic Name

English

2-((4-(PYRIDIN-2-YL)PIPERAZIN-1-YL)METHYL)-1H-BENZIMIDAZOLE

Systematic Name

English

Code System Code Type Description

FDA UNII

4WV2575JWT