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Details

Stereochemistry ACHIRAL
Molecular Formula C9H19NO3S
Molecular Weight 221.317
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of 3-(CYCLOHEXYLAMINO)PROPANESULFONIC ACID

SMILES

OS(=O)(=O)CCCNC1CCCCC1

InChI

InChIKey=PJWWRFATQTVXHA-UHFFFAOYSA-N
InChI=1S/C9H19NO3S/c11-14(12,13)8-4-7-10-9-5-2-1-3-6-9/h9-10H,1-8H2,(H,11,12,13)

HIDE SMILES / InChI

Molecular Formula C9H19NO3S
Molecular Weight 221.317
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

3-(CYCLOHEXYLAMINO)PROPANESULFONIC ACID (CAPS) is a zwitterionic biological buffer which has minimal reactivity with enzymes or proteins and minimal salt effects. CAPS buffer is widely used in Western and immunoblotting experiments as well as protein sequencing and identification. The high pH of this buffer makes it useful for the transfer of proteins with a pI > 8.5. CAPS has been used to study pH-dependent processes in enzymology and as an eluent buffer component in the separation of basic drugs by HPLC.

Approval Year

PubMed

PubMed

TitleDatePubMed
Expression and prognostic significance of lysozyme in male breast cancer.
2002
Direct monitoring of the expression of the green fluorescent protein-extracellular signal-regulated kinase 2 fusion protein in transfected cells using capillary electrophoresis with laser-induced fluorescence detection.
2002 Nov 8
Simultaneous determination of norepinephrine, serotonin, and 5-hydroxyindole-3-acetic acid in microdialysis samples from rat brain by microbore column liquid chromatography with fluorescence detection following derivatization with benzylamine.
2003 Jan 15
Simultaneous determination of 5-hydroxyindoles and catechols by high-performance liquid chromatography with fluorescence detection following derivatization with benzylamine and 1,2-diphenylethylenediamine.
2003 Sep 19
Analysis of tryptophan and tyrosine in cerebrospinal fluid by capillary electrophoresis and "ball lens" UV-pulsed laser-induced fluorescence detection.
2003 Sep 26
Determination of serotonin, noradrenaline, dopamine and their metabolites in rat brain extracts and microdialysis samples by column liquid chromatography with fluorescence detection following derivatization with benzylamine and 1,2-diphenylethylenediamine.
2004 Aug 5
Fast speciation analysis of iodophenol compounds in river waters by capillary electrophoresis-inductively coupled plasma-mass spectrometry with off-line solid-phase microextraction.
2004 Jun
The role of CAPS buffer in expanding the crystallization space of the nucleotide-binding domain of the ABC transporter haemolysin B from Escherichia coli.
2004 Jun
The effects of oxidative stress in urinary tract infection.
2005 Aug 31
Oxidative stress in patients with nongenital warts.
2005 Aug 31
Bishistidyl heme hexacoordination, a key structural property in Drosophila melanogaster hemoglobin.
2005 Jul 22
Estimation of logP(ow) values for neutral and basic compounds by microchip microemulsion electrokinetic chromatography with indirect fluorimetric detection (muMEEKC-IFD).
2005 Jun 1
Optimised two-dimensional electrophoresis procedures for the protein characterisation of structural tissues.
2005 May
Chiral ligand exchange micellar electrokinetic chromatography using borate anion as a central ion.
2005 Oct
Cactus pear: a natural product in cancer chemoprevention.
2005 Sep 8
Changes in endopolygalacturonase levels and characterization of a putative endo-PG gene during fruit softening in peach genotypes with nonmelting and melting flesh fruit phenotypes.
2006
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage site.
2006
Suppressed anion chromatography using mixed zwitter-ionic and carbonate eluents.
2006 Jun 16
Disruption of nucleocytoplasmic trafficking of cyclin D1 and topoisomerase II by sanguinarine.
2006 Mar 2
Analytical separation of Au/Ag core/shell nanoparticles by capillary electrophoresis.
2006 Nov 10
On-line enhancement and separation of nanoparticles using capillary electrophoresis.
2007 Aug 17
Mechanism of proton transfer in the 3alpha-hydroxysteroid dehydrogenase/carbonyl reductase from Comamonas testosteroni.
2007 Nov 23
A high-efficiency capillary electrophoresis-based method for characterizing the sizes of Au nanoparticles.
2007 Oct 12
Identification and characterization of a plastid-localized Arabidopsis glyoxylate reductase isoform: comparison with a cytosolic isoform and implications for cellular redox homeostasis and aldehyde detoxification.
2008
A dual role for integrin-linked kinase in platelets: regulating integrin function and alpha-granule secretion.
2008 Dec 1
High-affinity IgE receptor-beta chain expression in human mast cells.
2008 Jul 31
The fungus Neurospora crassa displays telomeric silencing mediated by multiple sirtuins and by methylation of histone H3 lysine 9.
2008 Nov 3
Stacking enhanced determination of steroids by CE.
2008 Sep
Biochemical characterization, mitochondrial localization, expression, and potential functions for an Arabidopsis gamma-aminobutyrate transaminase that utilizes both pyruvate and glyoxylate.
2009
Using micellar electrokinetic chromatography for the highly efficient preconcentration and separation of gold nanoparticles.
2009 Mar 20
Molecular biosensing mechanisms in the spleen for the removal of aged and damaged red cells from the blood circulation.
2010
Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins.
2010
Low aerobic mitochondrial energy metabolism in poorly- or undifferentiated neuroblastoma.
2010 Apr 19
Identification of calcium-binding proteins associated with the human sperm plasma membrane.
2010 Jan 15
Speciation analysis of arsenic and selenium compounds by CE-dynamic reaction cell-ICP-MS.
2010 Jul
Evaluating binuclear copper(II) complexes for glycoside hydrolysis.
2010 Mar 15
Rhizobium leguminosarum bv. trifolii rosR is required for interaction with clover, biofilm formation and adaptation to the environment.
2010 Nov 11
Genetic background modifies neurodegeneration and neuroinflammation driven by misfolded human tau protein in rat model of tauopathy: implication for immunomodulatory approach to Alzheimer's disease.
2010 Oct 12
Human primordial germ cell formation is diminished by exposure to environmental toxicants acting through the AHR signaling pathway.
2010 Sep

Sample Use Guides

quail: LD50 oral > 316mg/kg (316mg/kg)
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Dec 16 04:02:32 GMT 2023
Edited
by admin
on Sat Dec 16 04:02:32 GMT 2023
Record UNII
4W981O1LXP
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
3-(CYCLOHEXYLAMINO)PROPANESULFONIC ACID
Systematic Name English
CAPS
MI  
Common Name English
3-(CYCLOHEXYLAMINO)-1-PROPANESULFONIC ACID
Systematic Name English
N-CYCLOHEXYL-3-AMINOPROPANESULFONIC ACID
Systematic Name English
WAS-12
Code English
CAPS [MI]
Common Name English
Code System Code Type Description
MERCK INDEX
m3039
Created by admin on Sat Dec 16 04:02:32 GMT 2023 , Edited by admin on Sat Dec 16 04:02:32 GMT 2023
PRIMARY Merck Index
ECHA (EC/EINECS)
214-492-1
Created by admin on Sat Dec 16 04:02:32 GMT 2023 , Edited by admin on Sat Dec 16 04:02:32 GMT 2023
PRIMARY
WIKIPEDIA
CAPS (buffer)
Created by admin on Sat Dec 16 04:02:32 GMT 2023 , Edited by admin on Sat Dec 16 04:02:32 GMT 2023
PRIMARY
PUBCHEM
70815
Created by admin on Sat Dec 16 04:02:32 GMT 2023 , Edited by admin on Sat Dec 16 04:02:32 GMT 2023
PRIMARY
CAS
1135-40-6
Created by admin on Sat Dec 16 04:02:32 GMT 2023 , Edited by admin on Sat Dec 16 04:02:32 GMT 2023
PRIMARY
DRUG BANK
DB02219
Created by admin on Sat Dec 16 04:02:32 GMT 2023 , Edited by admin on Sat Dec 16 04:02:32 GMT 2023
PRIMARY
EPA CompTox
DTXSID3061554
Created by admin on Sat Dec 16 04:02:32 GMT 2023 , Edited by admin on Sat Dec 16 04:02:32 GMT 2023
PRIMARY
FDA UNII
4W981O1LXP
Created by admin on Sat Dec 16 04:02:32 GMT 2023 , Edited by admin on Sat Dec 16 04:02:32 GMT 2023
PRIMARY