18-HYDROXYCORTICOSTERONE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C21H30O5
Molecular Weight	362.4599
Optical Activity	UNSPECIFIED
Defined Stereocenters	7 / 7
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CC[C@H](C(=O)CO)[C@@]1(CO)C[C@H](O)[C@@]3([H])[C@@]2([H])CCC4=CC(=O)CC[C@]34C

InChI

InChIKey=HFSXHZZDNDGLQN-ZVIOFETBSA-N

InChI=1S/C21H30O5/c1-20-7-6-13(24)8-12(20)2-3-14-15-4-5-16(18(26)10-22)21(15,11-23)9-17(25)19(14)20/h8,14-17,19,22-23,25H,2-7,9-11H2,1H3/t14-,15-,16+,17-,19+,20-,21+/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H30O5
Molecular Weight	362.4599
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	6 / 7
E/Z Centers	0
Optical Activity	UNSPECIFIED

Approval Year

PubMed

Title	Date	PubMed
Clinical response to metyrapone as indicated by measurement of mineralocorticoids and glucocorticoids in normal children.	1981 Jan	7226574
Direct radioimmunoassays for "aldosterone" and "18-hydroxycorticosterone" in unprocessed urine, and their use in screening to distinguish primary aldosteronism from hypertension.	1982 Mar	7067086
In vivo and in vitro studies on steroid metabolism in a case of primary aldosteronism with multiple lesions of adenoma and nodular hyperplasia.	1982 Oct	6303762
Aldosterone metabolites and possible aldosterone precursors in hypertension.	1983 Jul	6887870
Effect of chronic adrenocorticotropin stimulation on the excretion of 18-hydroxycortisol and 18-oxocortisol.	1988 Aug	2839536
Type 1 aldosterone synthase deficiency presenting in a middle-aged man.	2001 Mar	11238478
Liver lesion detection and characterization in patients with colorectal cancer: a comparison of low radiation dose non-enhanced PET/CT, contrast-enhanced PET/CT, and liver MRI.	2008 Sep-Oct	18830103
Synthesis, biological evaluation, and molecular modeling of 1-benzyl-1H-imidazoles as selective inhibitors of aldosterone synthase (CYP11B2).	2010 Feb 25	20121113

Patents

Substance Class	Chemical Created by `admin` on `Sat Dec 16 01:32:28 GMT 2023` Edited by `admin` on `Sat Dec 16 01:32:28 GMT 2023`
Record UNII	4U5T0O9SI3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

18-HYDROXYCORTICOSTERONE

Common Name

English

PREGN-4-ENE-3,20-DIONE, 11,18,21-TRIHYDROXY-, (11.BETA.)-

Systematic Name

English

PREGN-4-ENE-3,20-DIONE, 11.BETA.,18,21-TRIHYDROXY-

Systematic Name

English

Classification Tree Code System Code

LOINC

50082-7