U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 13:40:49 GMT 2025
Edited
by admin
on Wed Apr 02 13:40:49 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1|KAPPA
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
4U47PC3GYR
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Remzistotug
INN  
Official Name English
GSK-4381562A
Preferred Name English
remzistotug [INN]
Common Name English
immunoglobulin G1-kappa, anti-[Homo sapiens PVRIG (poliovirus receptor (PVR) related immunoglobulin domain containing, NECTIN2 receptor, CD112 receptor, CD112R)], Homo sapiens monoclonal antibody
Common Name English
Immunoglobulin G1, anti-(human transmembrane protein PVRIG) (human monoclonal GSK4381562A ?1-chain), disulfide with human monoclonal GSK4381562A ?-chain, dimer
Common Name English
GSK4381562A
Code English
H-gamma1 heavy chain Homo sapiens (1-453) [VH (Homo sapiens IGHV1-69*10 (95.9%) -(IGHD) -IGHJ5*02 (100%), CDR-IMGT [8.8.16] (26-33.51-58.97-112)) (1-123) -Homo sapiens IGHG1*01 (100%) G1m17,1 CH1 K120, CH3 D12, L14 (CH1 K120 (220) (124-221), hinge 1-15 (
Common Name English
Code System Code Type Description
INN
13149
Created by admin on Wed Apr 02 13:40:49 GMT 2025 , Edited by admin on Wed Apr 02 13:40:49 GMT 2025
PRIMARY
SMS_ID
300000046772
Created by admin on Wed Apr 02 13:40:49 GMT 2025 , Edited by admin on Wed Apr 02 13:40:49 GMT 2025
PRIMARY
CAS
2920425-39-2
Created by admin on Wed Apr 02 13:40:49 GMT 2025 , Edited by admin on Wed Apr 02 13:40:49 GMT 2025
PRIMARY
FDA UNII
4U47PC3GYR
Created by admin on Wed Apr 02 13:40:49 GMT 2025 , Edited by admin on Wed Apr 02 13:40:49 GMT 2025
PRIMARY
NCI_THESAURUS
C187105
Created by admin on Wed Apr 02 13:40:49 GMT 2025 , Edited by admin on Wed Apr 02 13:40:49 GMT 2025
PRIMARY
From To
1_22 1_96
2_22 2_96
2_150 2_206
2_226 4_213
2_267 2_327
1_150 1_206
2_373 2_431
3_23 3_88
3_133 3_193
4_23 4_88
4_133 4_193
1_226 3_213
1_232 2_232
1_235 2_235
1_267 1_327
1_373 1_431
Glycosylation Link Type Site
N 1_303
N 2_303
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID REMOVAL [1_453] [2_453] C-TERMINUS K LYSINE K3Z4F929H6
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS Q PIDOLIC ACID SZB83O1W42
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL