U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS
Alicaforsen is an antisense oligonucleotide targeted to down regulate the production of ICAM-1, a cell surface receptor which is involved in the process of inflammation. Alicaforsen selectively inhibits ICAM‑1 gene expression. Over-expression of ICAM‑1 occurs in a wide variety of inflammatory disorders, including ulcerative colitis (UC), pouchitis and tissues in the eye, gastrointestinal teact, lungs and skin. Alicaforsen is currently in development for the treatment of IBD. An enema formulation is currently in a pivotal Phase 3 study agreed with U.S., Canadian and European regulatory agencies in patients with active pouchitis. The study has completed enrollment of patients to approximately 40 trial centres across the U.S., Canada, Europe, and Israel, and is expected to report preliminary data in H1 2019. Under a rolling submission agreement with the FDA, Atlantic Healthcare has filed the nonclinical data package of its New Drug Application (NDA) for alicaforsen to treat pouchitis with the regulator. Alicaforsen has also been granted FDA Fast-Track designation, plus U.S. and European Orphan Drug designations for this indication. ​

Approval Year

PubMed

PubMed

TitleDatePubMed
Alicaforsen in the treatment of pouchitis.
2017 Nov

Sample Use Guides

Pouchitis: Alicaforsen enema, 240mg once daily for 6 weeks
Route of Administration: Rectal
Alicaforsen demonstrated hyperbolic, mixed-type inhibition of chromogenic substrate cleavage by factor IXa (K(I) = 88 nM). Equilibrium binding studies with fluorescein-labeled Alicaforsen demonstrated a similar affinity (K(D) = 92 nM) for the PS ODN-factor IX interaction.
Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 13:39:11 GMT 2023
Edited
by admin
on Sat Dec 16 13:39:11 GMT 2023
Nucleic Acid Type OLIGONUCLEOTIDE
Nucleic Acid Subtype
Record UNII
4TWN6SZB8W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALICAFORSEN SODIUM
MART.   USAN   WHO-DD  
USAN  
Official Name English
ALICAFORSEN NONADECASODIUM SALT
MI  
Common Name English
ISIS 2302
Code English
ALICAFORSEN SODIUM [USAN]
Common Name English
ISIS-2302
Code English
DNA, D((R)-P-THIO)(G-C-C-C-A-A-G-C-T-G-G-C-A-T-C-C-G-T-C-A) NONADECASODIUM SALT
Common Name English
Alicaforsen sodium [WHO-DD]
Common Name English
ALICAFORSEN SODIUM [MART.]
Common Name English
ALICAFORSEN NONADECASODIUM SALT [MI]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C1291
Created by admin on Sat Dec 16 13:39:11 GMT 2023 , Edited by admin on Sat Dec 16 13:39:11 GMT 2023
Code System Code Type Description
DRUG BANK
DBSALT002000
Created by admin on Sat Dec 16 13:39:11 GMT 2023 , Edited by admin on Sat Dec 16 13:39:11 GMT 2023
PRIMARY
ChEMBL
CHEMBL2108895
Created by admin on Sat Dec 16 13:39:11 GMT 2023 , Edited by admin on Sat Dec 16 13:39:11 GMT 2023
PRIMARY
NCI_THESAURUS
C142911
Created by admin on Sat Dec 16 13:39:11 GMT 2023 , Edited by admin on Sat Dec 16 13:39:11 GMT 2023
PRIMARY
MERCK INDEX
m1507
Created by admin on Sat Dec 16 13:39:11 GMT 2023 , Edited by admin on Sat Dec 16 13:39:11 GMT 2023
PRIMARY Merck Index
USAN
LL-97
Created by admin on Sat Dec 16 13:39:11 GMT 2023 , Edited by admin on Sat Dec 16 13:39:11 GMT 2023
PRIMARY
FDA UNII
4TWN6SZB8W
Created by admin on Sat Dec 16 13:39:11 GMT 2023 , Edited by admin on Sat Dec 16 13:39:11 GMT 2023
PRIMARY
PUBCHEM
16197723
Created by admin on Sat Dec 16 13:39:11 GMT 2023 , Edited by admin on Sat Dec 16 13:39:11 GMT 2023
PRIMARY
MESH
C089753
Created by admin on Sat Dec 16 13:39:11 GMT 2023 , Edited by admin on Sat Dec 16 13:39:11 GMT 2023
PRIMARY
CAS
331257-52-4
Created by admin on Sat Dec 16 13:39:11 GMT 2023 , Edited by admin on Sat Dec 16 13:39:11 GMT 2023
PRIMARY
EVMPD
SUB194620
Created by admin on Sat Dec 16 13:39:11 GMT 2023 , Edited by admin on Sat Dec 16 13:39:11 GMT 2023
PRIMARY
Sugar Site Range Site Count
Deoxyribose (DNA) 1_1-1_20 20 / 20
Linkage Site Range Site Count
Sodium Phosporothioate 1_2-1_20 19 / 19
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY