U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Thu Jul 06 14:54:59 UTC 2023
Edited
by admin
on Thu Jul 06 14:54:59 UTC 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
4TVX2I407K
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
TUMOR NECROSIS FACTOR-.ALPHA. HUMAN (PLASMA DERIVED, SOLUBLE FORM)
Common Name English
TNF-.ALPHA.
Common Name English
TUMOR NECROSIS FACTOR-.ALPHA. HUMAN (SOLUBLE FORM)
Common Name English
TUMOR NECROSIS FACTOR-.ALPHA. (SOLUBLE FORM)
Common Name English
Tumor necrosis factor alpha [WHO-DD]
Common Name English
TUMOR NECROSIS FACTOR .ALPHA. HUMAN (SOLUBLE FORM)
Common Name English
CACHECTIN
Common Name English
TUMOR NECROSIS FACTOR-ALPHA
Common Name English
TUMOR NECROSIS FACTOR-.ALPHA.
Common Name English
Code System Code Type Description
CAS
308079-78-9
Created by admin on Thu Jul 06 14:55:01 UTC 2023 , Edited by admin on Thu Jul 06 14:55:01 UTC 2023
PRIMARY
EPA CompTox
DTXSID4040634
Created by admin on Thu Jul 06 14:55:01 UTC 2023 , Edited by admin on Thu Jul 06 14:55:01 UTC 2023
PRIMARY
MESH
D014409
Created by admin on Thu Jul 06 14:55:01 UTC 2023 , Edited by admin on Thu Jul 06 14:55:01 UTC 2023
PRIMARY
PUBCHEM
161495
Created by admin on Thu Jul 06 14:55:01 UTC 2023 , Edited by admin on Thu Jul 06 14:55:01 UTC 2023
PRIMARY
FDA UNII
4TVX2I407K
Created by admin on Thu Jul 06 14:55:01 UTC 2023 , Edited by admin on Thu Jul 06 14:55:01 UTC 2023
PRIMARY
EVMPD
SUB75902
Created by admin on Thu Jul 06 14:55:01 UTC 2023 , Edited by admin on Thu Jul 06 14:55:01 UTC 2023
PRIMARY
From To
3_69 3_101
2_69 2_101
1_69 1_101
Glycosylation Type HUMAN
Glycosylation Link Type Site
O 1_3
O 2_3
O 3_3
Related Record Type Details
INHIBITOR -> TARGET
SELECTIVE
INHIBITOR -> TARGET
INHIBITOR OF RELEASE->TARGET
In human PBMCs
IC50
INHIBITOR -> TARGET
BINDING
INHIBITOR -> TARGET
N-acetylcysteine inhibited the TNF-α-stimulated production of cytokines and chemokines
INHIBITOR -> TARGET
INHIBITOR OF RELEASE->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
BINDING
INHIBITOR -> TARGET
INHIBITOR -> TARGET
BINDING
INHIBITOR OF EXPRESSION->TARGET
Directed against TNF.alpha. mRNA
INHIBITOR -> TARGET
INHIBITOR -> TARGET
BINDING
INHIBITOR -> TARGET
BINDING
INHIBITOR -> TARGET
T-CELLS->EXPRESSED PROTEIN
upon activation
INHIBITOR -> TARGET
BINDING
INHIBITOR -> TARGET
ACTIVATOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITS PDE4 AND INCREASES cAMP CONCENTRATION
INDIRECT
INHIBITOR OF EXPRESSION->TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Inhibition of LPS-induced TNF-α release from human monocytes
INHIBITOR -> TARGET
BINDING
MODULATOR->TARGET
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
Molecular Formula CHEMICAL
MOL_WEIGHT:CALCULATED CHEMICAL