Atisnolerbart

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 17:19:48 GMT 2023` Edited by `admin` on `Sat Dec 16 17:19:48 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	4S1L0R6IJG
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Atisnolerbart

Official Name

English

atisnolerbart [INN]

Common Name

English

immunoglobulin G4-kappa, anti-[Bet v 1 (Betula alleghaniensis (yellow birch) pollen allergen 1]

Common Name

English

gamma4 heavy chain Homo sapiens (1-447) [VH (Homo sapiens IGHV1-8*03 (86.7%) -(IGHD) - IGHJ4*01 (93.3%), CDR-IMGT [8.8.13] (26-33.51- 58.97-109)) (1-120)-Homo sapiens IGHG4*01, G4v5 h P10, nG4m(a) CH2 L92 (CH1 (121-218), hinge 1-12 S10>P (228) (219-230),

Common Name

English

Code System Code Type Description

INN

12259

Created by admin on Sat Dec 16 17:19:48 GMT 2023 , Edited by admin on Sat Dec 16 17:19:48 GMT 2023

PRIMARY

NCI_THESAURUS

C190335

Created by admin on Sat Dec 16 17:19:48 GMT 2023 , Edited by admin on Sat Dec 16 17:19:48 GMT 2023

PRIMARY

FDA UNII

4S1L0R6IJG

Created by admin on Sat Dec 16 17:19:48 GMT 2023 , Edited by admin on Sat Dec 16 17:19:48 GMT 2023

PRIMARY

CAS

2456308-79-3

Created by admin on Sat Dec 16 17:19:48 GMT 2023 , Edited by admin on Sat Dec 16 17:19:48 GMT 2023

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_134	4_215
2_147	2_203
2_261	2_321
1_134	3_215
2_367	2_425
3_23	3_89
3_135	3_195
4_23	4_89
4_135	4_195
1_147	1_203
1_226	2_226
1_229	2_229
1_261	1_321
1_367	1_425

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_297
N	2_297

Related Record Type Details


					4S1L0R6IJG

Atisnolerbart

ACTIVE MOIETY

Comments:

As determined using SPR technology, the REGN5713, REGN5714, and REGN5715 equilibrium dissociation constants (KD) for nBet v 1 were 187, 933, and 747pM, respectively (Module 2.6.2 Section 2.1.1). REGN5713, REGN5714, and REGN5715 also bound rCar b 1 with KD values of 2.16, 59.1, and 1.91nM, respectively

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL