Gotistobart

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 15:39:36 GMT 2023` Edited by `admin` on `Sat Dec 16 15:39:36 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	4R46M31XXP
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Gotistobart

Official Name

English

gotistobart [INN]

Common Name

English

Gamma1 heavy chain humanized (1-454) [VH (Homo sapiens IGHV4-59*01 (86.6%) -(IGHD) -IGHJ4*01(92.9%), CDR-IMGT [8.7.19] (26-33.51-57.96-114)) (1-125)-Homo sapiens IGHG1*01, G1m17,1 CH1 K120CH3 D12, L14, G1v6CH2 A85.4, A118, A119, G1v21CH2 Y15.1, T16, E18

Common Name

English

ONC-392

Code

English

Gotistobart (immunoglobulin G1-kappa, anti-[Homo sapiens CTLA4(cytotoxic T-lymphocyte-associated protein 4, CTLA-4, CD152)], humanized monoclonal antibody)

Common Name

English

ONC 392 [WHO-DD]

Common Name

English

Code System Code Type Description

INN

12383

Created by admin on Sat Dec 16 15:39:36 GMT 2023 , Edited by admin on Sat Dec 16 15:39:36 GMT 2023

PRIMARY

NCI_THESAURUS

C173547

Created by admin on Sat Dec 16 15:39:36 GMT 2023 , Edited by admin on Sat Dec 16 15:39:36 GMT 2023

PRIMARY

FDA UNII

4R46M31XXP

Created by admin on Sat Dec 16 15:39:36 GMT 2023 , Edited by admin on Sat Dec 16 15:39:36 GMT 2023

PRIMARY

CAS

2226344-78-9

Created by admin on Sat Dec 16 15:39:36 GMT 2023 , Edited by admin on Sat Dec 16 15:39:36 GMT 2023

PRIMARY

CLINICAL_TRIALS.GOV

NCT04140526

Created by admin on Sat Dec 16 15:39:36 GMT 2023 , Edited by admin on Sat Dec 16 15:39:36 GMT 2023

PRIMARY

From	To
1_22	1_95
2_22	2_95
2_152	2_208
2_269	2_329
1_152	1_208
2_375	2_433
1_234	2_234
1_237	2_237
1_269	1_329
1_375	1_433
1_228	3_214
2_228	4_214
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_305
N	2_305

Related Record Type Details


					4R46M31XXP

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL