Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C21H20O9 |
| Molecular Weight | 416.3781 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC[C@H]1O[C@@H](OC2=CC=C3C(=O)C(=COC3=C2)C4=CC=C(O)C=C4)[C@H](O)[C@@H](O)[C@@H]1O
InChI
InChIKey=KYQZWONCHDNPDP-QNDFHXLGSA-N
InChI=1S/C21H20O9/c22-8-16-18(25)19(26)20(27)21(30-16)29-12-5-6-13-15(7-12)28-9-14(17(13)24)10-1-3-11(23)4-2-10/h1-7,9,16,18-23,25-27H,8H2/t16-,18-,19+,20-,21-/m1/s1
| Molecular Formula | C21H20O9 |
| Molecular Weight | 416.3781 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
The three major isoflavones present in kudzu extracts, daidzin, daidzein and puerarin are responsible for the beneficial effects in reduction of alcohol consumption. It has been discovered, that daidzin was a strong, selective and reversible inhibitor of mitochondrial aldehyde dehydrogenase. Daidzin did not inhibit human class I, II, or III alcohol dehydrogenases. However further studies for daidzin’s treatment in alcohol addiction were discontinued.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Suppressive effects of dietary genistin and daidzin on rat prostate carcinogenesis. | 2000 Aug |
|
| Intestinal bacteria activate estrogenic effect of main constituents puerarin and daidzin of Pueraria thunbergiana. | 2006 Dec |
|
| Absorption and metabolism of Astragali radix decoction: in silico, in vitro, and a case study in vivo. | 2006 Jun |
|
| Prediction of estrogen receptor agonists and characterization of associated molecular descriptors by statistical learning methods. | 2006 Nov |
|
| Bioactive flavonoids of the flowers of Butea monosperma. | 2009 Apr |
|
| Role of plasma lipoproteins in the transport of the soyabean isoflavones daidzein and daidzein-7-O-beta-D-glucoside. | 2009 Sep |
|
| The effects of daidzin and its aglycon, daidzein, on the scopolamine-induced memory impairment in male mice. | 2010 Oct |
|
| Discovery of novel regulators of aldehyde dehydrogenase isoenzymes. | 2011 May 30 |
|
| Methylmercury impairs canonical dopamine metabolism in rat undifferentiated pheochromocytoma (PC12) cells by indirect inhibition of aldehyde dehydrogenase. | 2015 Apr |
Sample Use Guides
in rats: orally administered at a dose of 7.9 micromol/kg in 25 mM Na2CO3
Route of Administration:
Oral
Human, hamster, and rat liver mitochondrial and cytosolic ALDH isozymes were used. ALDH activity was assayed by monitoring the increase in absorbance at 340 nm due to the formation of NADH when acetaldehyde was used as the substrate. The range of concentration of saidzin were: 0 - 2.4 uM. It was shown, that daidzin potently inhibited hamster and rat ALDH-2 and, as for the human enzyme, the inhibition was mixed. The daidzin Ki values for hamster and rat ALDH-2 are 0.082 and 0.052 uM, respectively, slightly higher than that for the human enzyme (0.042 uM).
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:54:45 UTC 2023
by
admin
on
Fri Dec 15 15:54:45 UTC 2023
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| Record UNII |
4R2X91A5M5
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| Record Status |
Validated (UNII)
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| Record Version |
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552-66-9
Created by
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DB02115
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1162432
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DAIDZIN
Created by
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C013908
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42202
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DTXSID00862180
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107971
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4R2X91A5M5
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m4068
Created by
admin on Fri Dec 15 15:54:45 UTC 2023 , Edited by admin on Fri Dec 15 15:54:45 UTC 2023
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| Related Record | Type | Details | ||
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PARENT -> CONSTITUENT ALWAYS PRESENT |
USP
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