U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 14:41:34 GMT 2023
Edited
by admin
on Sat Dec 16 14:41:34 GMT 2023
Protein Type RECEPTOR
Protein Sub Type GROWTH FACTOR RECEPTOR
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
4P6Y9ZK0WL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
EPIDERMAL GROWTH FACTOR RECEPTOR L858R MUTANT
Common Name English
EGFR L858R
Common Name English
EGFR L858R MUTATION
Common Name English
Code System Code Type Description
FDA UNII
4P6Y9ZK0WL
Created by admin on Sat Dec 16 14:41:35 GMT 2023 , Edited by admin on Sat Dec 16 14:41:35 GMT 2023
PRIMARY
UNIPROT
P00533
Created by admin on Sat Dec 16 14:41:35 GMT 2023 , Edited by admin on Sat Dec 16 14:41:35 GMT 2023
PRIMARY
From To
1_7 1_34
1_133 1_163
1_166 1_175
1_170 1_183
1_191 1_199
1_195 1_207
1_208 1_216
1_212 1_224
1_227 1_236
1_240 1_267
1_271 1_283
1_287 1_302
1_305 1_309
1_313 1_338
1_446 1_475
1_482 1_491
1_486 1_499
1_502 1_511
1_515 1_531
1_534 1_547
1_538 1_555
1_558 1_567
1_571 1_593
1_596 1_604
1_600 1_612
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_104
N 1_151
N 1_172
N 1_328
N 1_337
N 1_389
N 1_420
N 1_504
N 1_544
N 1_579
N 1_599
Related Record Type Details
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IRREVERSIBLE INHIBITOR
IC50
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Potent irreversible inhibitor of EGFR harbouring resistance (T790M) or activating (L858R and exon 19 deletions) mutations [6]. The half maximal inhibitory concentration (IC50) of furmonertinib against these mutant EGFRs is ≈ 1 nmol/L, which is lower than its IC50 against wild-type EGFR.
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
IC50
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER AVERAGE(CALCULATED) CHEMICAL