Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C24H24N5O15P3 |
| Molecular Weight | 715.3931 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](OC(=O)C4=CC=C(C=C4)C(=O)C5=CC=CC=C5)[C@H]3O)C2=NC=N1
InChI
InChIKey=AWJJLYZBWRIBCZ-UGTJMOTHSA-N
InChI=1S/C24H24N5O15P3/c25-21-17-22(27-11-26-21)29(12-28-17)23-19(31)20(16(41-23)10-40-46(36,37)44-47(38,39)43-45(33,34)35)42-24(32)15-8-6-14(7-9-15)18(30)13-4-2-1-3-5-13/h1-9,11-12,16,19-20,23,31H,10H2,(H,36,37)(H,38,39)(H2,25,26,27)(H2,33,34,35)/t16-,19-,20-,23-/m1/s1
| Molecular Formula | C24H24N5O15P3 |
| Molecular Weight | 715.3931 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacological characterization of the human P2Y11 receptor. | 1999 Nov |
|
| Regulation of phospholipase D by P2X7 receptors in submandibular ductal cells. | 2003 Oct |
|
| Stimulation of P2X7 receptors elevates Ca2+ and kills retinal ganglion cells. | 2005 Jun |
|
| P2X(7) receptor blockade prevents ATP excitotoxicity in oligodendrocytes and ameliorates experimental autoimmune encephalomyelitis. | 2007 Aug 29 |
|
| Pharmacological characterization of pannexin-1 currents expressed in mammalian cells. | 2009 Feb |
|
| Characterization of protoberberine analogs employed as novel human P2X7 receptor antagonists. | 2011 Apr 15 |
|
| Microglial zinc uptake via zinc transporters induces ATP release and the activation of microglia. | 2011 Dec |
|
| Expression and functional characterization of P2X receptors in mouse alveolar macrophages. | 2011 Sep |
|
| Purinergic P2X7 receptors mediate cell death in mouse cerebellar astrocytes in culture. | 2013 Dec |
|
| P2X7 receptors at adult neural progenitor cells of the mouse subventricular zone. | 2013 Oct |
|
| The azetidine derivative, KHG26792 protects against ATP-induced activation of NFAT and MAPK pathways through P2X7 receptor in microglia. | 2015 Dec |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 18:11:06 GMT 2023
by
admin
on
Fri Dec 15 18:11:06 GMT 2023
|
| Record UNII |
4P5DXU1F8Q
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| Record Status |
Validated (UNII)
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| Record Version |
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DTXSID00100222
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4P5DXU1F8Q
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81790-82-1
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115205
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C033901
Created by
admin on Fri Dec 15 18:11:06 GMT 2023 , Edited by admin on Fri Dec 15 18:11:06 GMT 2023
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