OXAMISOLE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C15H20N2O2.ClH
Molecular Weight	296.792
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.COC1(CCCN2CC(N=C12)C3=CC=CC=C3)OC

InChI

InChIKey=SDIVEYBYOHLVIP-UHFFFAOYSA-N

InChI=1S/C15H20N2O2.ClH/c1-18-15(19-2)9-6-10-17-11-13(16-14(15)17)12-7-4-3-5-8-12;/h3-5,7-8,13H,6,9-11H2,1-2H3;1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C15H20N2O2
Molecular Weight	260.3315
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3263341 | https://www.ncbi.nlm.nih.gov/pubmed/2177037 | https://adisinsight.springer.com/drugs/800001048

Oxamisole (previously known as PR 879-317A), a selective immunomodulatory agent that was studied for the treatment of viral infections. Experiments on mice have shown that antiviral properties of oxamisole were mediated through the immunomodulatory effects of this compound on the immune system. However, further development of this drug was discontinued.

Originator

Approval Year

PubMed

Title	Date	PubMed
PR 879-317A enhances in vitro immune activity of peripheral blood mononuclear cells from patients with Down syndrome.	1987	2962955
Inhibition of murine hepatitis virus infections by the immunomodulator 2,3,5,6,7,8-hexahydro-2-phenyl-8,8-dimethoxy-imidazo[1,2a]pyridine (PR-879-317A).	1987 Jul	2821891
The immunological profile of a new immunomodulatory agent, oxamisole.	1988	3263341
Immunomodulator effects on the Friend virus infection in genetically defined mice.	1993 Jun 23	8363251

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:52:18 GMT 2023` Edited by `admin` on `Fri Dec 15 17:52:18 GMT 2023`
Record UNII	4OW8JJS90Z
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OXAMISOLE HYDROCHLORIDE

Official Name

English

PR-879-317A

Code

English

PR-879317A

Code

English

IMIDAZO(1,2-A)PYRIDINE, 2,3,5,6,7,8-HEXAHYDRO-8,8-DIMETHOXY-2-PHENYL-, MONOHYDROCHLORIDE, (±)-

Common Name

English

OXAMISOLE HYDROCHLORIDE [USAN]

Common Name

English

PR 879-317A

Code

English

(±)-2,3,6,7-TETRAHYDRO-2-PHENYLIMIDAZO(1,2-A)PYRIDIN-8(5H)-ONE, DIMETHYL ACETAL, MONOHYDROCHLORIDE

Common Name

English

Code System Code Type Description

MESH

C053269