U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Sat Dec 16 13:55:47 GMT 2023
Edited
by admin
on Sat Dec 16 13:55:47 GMT 2023
Protein Type PEPTIDE
Protein Sub Type ANTI-APOPTOCTIC REGULATORY PROTEIN
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
4LUD924Y4D
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
E3 UBIQUITIN-PROTEIN LIGASE XIAP
Common Name English
API3
Common Name English
XIAP
Common Name English
BIRC4
Common Name English
IAP-LIKE PROTEIN
Common Name English
X-LINKED INHIBITOR OF APOPTOSIS PROTEIN
Common Name English
INHIBITOR OF APOPTOSIS PROTEIN 3
Common Name English
BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4
Common Name English
RING-TYPE E3 UBIQUITIN TRANSFERASE XIAP
Common Name English
IAP3
Common Name English
Code System Code Type Description
FDA UNII
4LUD924Y4D
Created by admin on Sat Dec 16 13:55:48 GMT 2023 , Edited by admin on Sat Dec 16 13:55:48 GMT 2023
PRIMARY
UNIPROT
P98170
Created by admin on Sat Dec 16 13:55:48 GMT 2023 , Edited by admin on Sat Dec 16 13:55:48 GMT 2023
PRIMARY
Related Record Type Details
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
INHIBITOR -> TARGET
APG-1387 in combination with TNF-α potently decreased NPC cell viability by inducing apoptosis in majority of NPC cell lines. Eight human IAP proteins and Smac mimetics activate caspases by antagonizing XIAP, which directly inhibits key caspase.
INHIBITOR -> TARGET
INHIBITOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL