Afatinib, (R)-

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C24H25ClFN5O3
Molecular Weight	485.938
Optical Activity	UNSPECIFIED
Defined Stereocenters	1 / 1
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN(C)C\C=C\C(=O)NC1=CC2=C(NC3=CC=C(F)C(Cl)=C3)N=CN=C2C=C1O[C@@H]4CCOC4

InChI

InChIKey=ULXXDDBFHOBEHA-QDLOVBKTSA-N

InChI=1S/C24H25ClFN5O3/c1-31(2)8-3-4-23(32)30-21-11-17-20(12-22(21)34-16-7-9-33-13-16)27-14-28-24(17)29-15-5-6-19(26)18(25)10-15/h3-6,10-12,14,16H,7-9,13H2,1-2H3,(H,30,32)(H,27,28,29)/b4-3+/t16-/m1/s1

HIDE SMILES / InChI

Molecular Formula	C24H25ClFN5O3
Molecular Weight	485.938
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	1 / 1
E/Z Centers	1
Optical Activity	UNSPECIFIED

Approval Year

Substance Class	Chemical Created by `admin` on `Wed Apr 02 17:18:58 GMT 2025` Edited by `admin` on `Wed Apr 02 17:18:58 GMT 2025`
Record UNII	4L4QT28LW3
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

(2E)-N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

Preferred Name

English

Afatinib, (R)-

Common Name

English

Afatinib impurity C

Common Name

English

2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-,

Systematic Name

English

(R,E)-N-(4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)-4-(dimethylamino)but-2-enamide

Systematic Name

English

(R)-Afatinib

Common Name

English

2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-

Systematic Name

English

N-[4-[(3-Chloro-4-fluorophenyl)amino]-7-[[(3R)-tetrahydro-3-furanyl]oxy]-6-quinazolinyl]-4-(dimethylamino)-2-butenamide

Systematic Name

English

Code System Code Type Description

CAS

945553-91-3

Created by admin on Wed Apr 02 17:18:58 GMT 2025 , Edited by admin on Wed Apr 02 17:18:58 GMT 2025

PRIMARY

PUBCHEM

10163178

Created by admin on Wed Apr 02 17:18:58 GMT 2025 , Edited by admin on Wed Apr 02 17:18:58 GMT 2025

PRIMARY

FDA UNII

4L4QT28LW3

Created by admin on Wed Apr 02 17:18:58 GMT 2025 , Edited by admin on Wed Apr 02 17:18:58 GMT 2025

PRIMARY

CAS

439081-17-1

Created by admin on Wed Apr 02 17:18:58 GMT 2025 , Edited by admin on Wed Apr 02 17:18:58 GMT 2025

NON-SPECIFIC STEREOCHEMISTRY