U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Protein
Created
by admin
on Wed Apr 02 10:03:25 GMT 2025
Edited
by admin
on Wed Apr 02 10:03:25 GMT 2025
Protein Type PROBODY
Protein Sub Type IGG1
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
4L1XJF3HGL
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
Muzastotug
Common Name English
ADG126
Preferred Name English
immunoglobulin G1- kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)], monoclonal antibody with cleavable prodomain; gamma1 heavy chain (1-446) [VH (Homo sapiens IGHV3-7*01 (77.8%) -(IGHD) -IGHJ4*01 (100%), CDR-
Common Name English
Immunoglobulin G1, anti-(human cytotoxic T-lymphocyte-associated protein 4) (human monoclonal ADG126 ?1-chain), disulfide with prodomain peptide (synthetic masking moiety and protease-cleavable moiety) fusion protein with human monoclonal ADG126 ?-chain,
Common Name English
Muzastotug (immunoglobulin G1-kappa, anti-[Homo sapiens CTLA4 (cytotoxic T-lymphocyte associated protein 4, CTLA-4, CD152)], humanized monoclonal antibody with cleavable prodomain)
Common Name English
muzastotug [INN]
Common Name English
Code System Code Type Description
INN
12573
Created by admin on Wed Apr 02 10:03:25 GMT 2025 , Edited by admin on Wed Apr 02 10:03:25 GMT 2025
PRIMARY
FDA UNII
4L1XJF3HGL
Created by admin on Wed Apr 02 10:03:25 GMT 2025 , Edited by admin on Wed Apr 02 10:03:25 GMT 2025
PRIMARY
CAS
2750031-18-4
Created by admin on Wed Apr 02 10:03:25 GMT 2025 , Edited by admin on Wed Apr 02 10:03:25 GMT 2025
PRIMARY
NCI_THESAURUS
C179276
Created by admin on Wed Apr 02 10:03:25 GMT 2025 , Edited by admin on Wed Apr 02 10:03:25 GMT 2025
PRIMARY
SMS_ID
300000048538
Created by admin on Wed Apr 02 10:03:25 GMT 2025 , Edited by admin on Wed Apr 02 10:03:25 GMT 2025
PRIMARY
From To
4_176 4_236
4_64 4_130
4_12 4_19
3_176 3_236
3_64 3_130
3_12 3_19
2_366 2_424
2_260 2_320
2_219 4_256
2_143 2_199
2_22 2_96
1_366 1_424
1_260 1_320
1_228 2_228
1_225 2_225
1_219 3_256
1_143 1_199
1_22 1_96
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_296
N 2_296

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS Amount: PIDOLIC ACID SZB83O1W42
AMINO ACID REMOVAL [1_446] [2_446] C-TERMINUS Amount: LYSINE K3Z4F929H6
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL