LARGE NEUTRAL AMINO ACID TRANSPORTER 1

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 20:51:11 GMT 2025` Edited by `admin` on `Tue Apr 01 20:51:11 GMT 2025`
Protein Type	TRANSPORTER
Protein Sub Type	AMINO ACID TRANSPORTER
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	4KHYO80GXC
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

4F2 CELL-SURFACE ANTIGEN HEAVY CHAIN AND LIGHT CHAIN

Preferred Name

English

LARGE NEUTRAL AMINO ACID TRANSPORTER 1

Common Name

English

SLC3A2 AND SLC7A5

Common Name

English

LAT-1

Common Name

English

CD-98

Common Name

English

LAT1

Common Name

English

CD98

Common Name

English

MDU1

Common Name

English

Code System Code Type Description

FDA UNII

4KHYO80GXC

Created by admin on Tue Apr 01 20:51:11 GMT 2025 , Edited by admin on Tue Apr 01 20:51:11 GMT 2025

PRIMARY

Glycosylation Type

HUMAN

Glycosylation Link Type	Site
N	1_365
N	1_381
N	1_424
N	1_506
N	2_49
N	2_230
N	2_340

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Comments:

LAT1 protein amount was the major determinant of BPA uptake at 100 ?M, whereas the contribution of ATB0,+ became significant at 1000 ?M, accounting for 20–25% of the total BPA uptake in MCF-7 breast cancer cells. Enhanced expression in tumor cells contribute significantly to the tumor accumulation of BPA at clinical dose.

Qualification:

Km

Amount:


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Amount:

Structural Modifications

Modification Type	Location Site	Residue Modified	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_103] [1_134] [1_165] [1_406] [1_408] [1_410] [1_527] [1_531] [2_31] [2_35]	S	DEXFOSFOSERINE	VI4F0K069V
AMINO_ACID_SUBSTITUTION	[1_1]		N-ACETYLMETHIONINE	9J12WX5B6A
AMINO_ACID_SUBSTITUTION	[1_106] [2_45]	T	THREONINE PHOSPHATE	3L4WX7B1EI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL