FX-909

Details

Stereochemistry	ACHIRAL
Molecular Formula	C17H10F2N2O3S
Molecular Weight	360.335
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

CS(=O)(=O)C1=CC=C(C=C1C2=CC(=O)C3=C(N2)C=C(F)C=C3F)C#N

InChI

InChIKey=RBUBBZVQPHSZEZ-UHFFFAOYSA-N

InChI=1S/C17H10F2N2O3S/c1-25(23,24)16-3-2-9(8-20)4-11(16)13-7-15(22)17-12(19)5-10(18)6-14(17)21-13/h2-7H,1H3,(H,21,22)

HIDE SMILES / InChI

Molecular Formula	C17H10F2N2O3S
Molecular Weight	360.335
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Approval Year

Substance Class	Chemical
Record UNII	4K58KV52ZM
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FX-909

Code

English

FX909

Preferred Name

English

Benzonitrile, 3-(5,7-difluoro-1,4-dihydro-4-oxo-2-quinolinyl)-4-(methylsulfonyl)-

Systematic Name

English

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Code System

Code

Type

Description

CAS

2924573-90-8

PRIMARY

NCI_THESAURUS

C201115

PRIMARY

FDA UNII

4K58KV52ZM

PRIMARY

PUBCHEM

167993670

PRIMARY

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Related Record

Type

Details


					AL17N8ZSWL

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA

TARGET->INVERSE AGONIST

Comments:

In cells covalently binds. FX-909 potently suppressed PPARG target gene mRNA at half maximal inhibitory concentration (IC50) values of 1-2 nM in cell lines that demonstrated activation of PPARG pathway signaling through RXRA mutation or PPARG amplification

Interaction Type:

IRREVERSIBLE INHIBITOR

Qualification:

IC50

Amount:

1 NANOMOLAR (average)

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Type

Details