Details
| Stereochemistry | RACEMIC |
| Molecular Formula | C15H19N3O2 |
| Molecular Weight | 273.3303 |
| Optical Activity | ( + / - ) |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC(C)NCC(O)COC1=C2C=C(NC2=CC=C1)C#N
InChI
InChIKey=ZDFQDGBLPBGVBY-UHFFFAOYSA-N
InChI=1S/C15H19N3O2/c1-10(2)17-8-12(19)9-20-15-5-3-4-14-13(15)6-11(7-16)18-14/h3-6,10,12,17-19H,8-9H2,1-2H3
| Molecular Formula | C15H19N3O2 |
| Molecular Weight | 273.3303 |
| Charge | 0 |
| Count |
|
| Stereochemistry | RACEMIC |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 1 |
| E/Z Centers | 0 |
| Optical Activity | ( + / - ) |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The role of the central serotonergic system in pilocarpine-induced seizures: receptor mechanisms. | 1989 Nov |
|
| Primary structure and functional characterization of a human 5-HT1D-type serotonin receptor. | 1991 Aug |
|
| Selective activation of beta3-adrenoceptors by octopamine: comparative studies in mammalian fat cells. | 1999 Apr |
|
| A 5-HT(7) receptor-mediated depolarization in the anterodorsal thalamus. I. Pharmacological characterization. | 2001 Apr |
|
| Abolition of (-)-CGP 12177-evoked cardiostimulation in double beta1/beta2-adrenoceptor knockout mice. Obligatory role of beta1-adrenoceptors for putative beta4-adrenoceptor pharmacology. | 2001 Jan |
|
| Colitis-induced alterations in adrenergic control of circular smooth muscle in vitro in rats. | 2001 Nov |
|
| BRL 37344 inhibited adrenergic transmission in the rat portal vein via atypical beta-adrenoceptors. | 2002 Apr |
|
| Specific labelling of serotonin 5-HT(1B) receptors in rat frontal cortex with the novel, phenylpiperazine derivative, [3H]GR125,743. A pharmacological characterization. | 2002 Apr |
|
| Serotonergic control of cerebellar mossy fiber activity by modulation of signal transfer by rat pontine nuclei neurons. | 2002 Aug |
|
| Altered expression of autonomic neurotransmitter receptors and proliferative responses in lymphocytes from a chronic mild stress model of depression: effects of fluoxetine. | 2002 Aug |
|
| Types of adrenoreceptors mediating responses of rabbit gastric muscularis mucosae. | 2002 Feb |
|
| Methiothepin attenuates gastric secretion and motility effects of vagal stimulants at the dorsal vagal complex. | 2002 Feb 1 |
|
| Hypothalamic-pituitary-thyroid axis and sympathetic nervous system involvement in hyperthermia induced by 3,4-methylenedioxymethamphetamine (Ecstasy). | 2003 Apr |
|
| Characterization of the 5-hydroxytryptamine receptors mediating contraction in the pig isolated intravesical ureter. | 2003 Jan |
|
| Beta 1-adrenoceptor selectivity of nebivolol and bisoprolol. A comparison of [3H]CGP 12.177 and [125I]iodocyanopindolol binding studies. | 2003 Jan 26 |
|
| [Impairment of atypical beta-adrenergic-mediated relaxation in spontaneously hypertensive rats before and during the development of arterial hypertension]. | 2003 Jul-Aug |
|
| Serotonin receptors involved in vasopressin and oxytocin secretion. | 2003 Mar |
|
| Modulatory effects on myocardial physiology induced by an anti-Trypanosoma cruzi monoclonal antibody involve recognition of major antigenic epitopes from beta1-adrenergic and M2-muscarinic cholinergic receptors without requiring receptor cross-linking. | 2004 Aug |
|
| Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. | 2004 Feb |
|
| Site-directed mutagenesis of the rat beta1-adrenoceptor. Involvement of Tyr356 (7.43) in (+/-)cyanopindolol but not (+/-)[125Iodo]cyanopindolol binding. | 2004 Jul |
|
| Functional responses of human beta1 adrenoceptors with defined haplotypes for the common 389R>G and 49S>G polymorphisms. | 2004 Jun |
|
| Characterization of mexiletine as an antagonist of beta-adrenoceptor in Chinese hamster ovary cells expressing cloned human beta-adrenoceptors. | 2004 Mar 1 |
|
| Impairment of the low-affinity state beta1-adrenoceptor-induced relaxation in spontaneously hypertensive rats. | 2004 Nov |
|
| Low-affinity state beta1-adrenoceptor-induced vasodilation in SHR. | 2005 Aug |
|
| Ligands at beta2-, beta3-, and the low-affinity state of beta1-adrenoceptors block the alpha1-adrenoceptor-mediated constriction in human pulmonary and rat mesenteric arteries. | 2005 Jul |
|
| Evidence for the presence of beta-3-adrenoceptors mediating relaxation in the human oviduct. | 2005 Jun |
|
| Evidence for pleiotropic signaling at the mouse beta3-adrenoceptor revealed by SR59230A [3-(2-Ethylphenoxy)-1-[(1,S)-1,2,3,4-tetrahydronapth-1-ylamino]-2S-2-propanol oxalate]. | 2005 Mar |
|
| Beta-adrenoceptor-mediated vascular relaxation in spontaneously hypertensive rats. | 2005 Mar 31 |
|
| Positive inotropic and lusitropic effects mediated via the low-affinity state of beta1-adrenoceptors in pithed rats. | 2005 Nov |
|
| 5-HT-stimulated [35S]guanosine-5'-O-(3-thio)triphosphate binding as an assay for functional activation of G proteins coupled with 5-HT1B receptors in rat striatal membranes. | 2006 Feb |
|
| 5-HT uptake blockade prevents the increasing effect of K(ATP) channel blockers on electrically evoked [3H]-5-HT release in rat and mouse neocortical slices. | 2006 Feb |
|
| Role of the G protein-coupled receptor kinase site serine cluster in beta2-adrenergic receptor internalization, desensitization, and beta-arrestin translocation. | 2006 Mar 17 |
|
| Potential involvement of a propranolol-insensitive atypical beta-adrenoceptor the vasodilator effect of cyanopindolol in the human pulmonary artery. | 2006 Sep |
|
| Serotonin increases the excitability of the hypothalamic paraventricular nucleus magnocellular neurons. | 2007 May |
|
| Adrenergic responses of rat colonic muscularis mucosae. | 2008 Aug |
|
| beta-adrenergic relaxation in pulmonary arteries: preservation of the endothelial nitric oxide-dependent beta2 component in pulmonary hypertension. | 2008 Jan |
|
| 5-HT excites globus pallidus neurons by multiple receptor mechanisms. | 2008 Jan 24 |
|
| Structure of a beta1-adrenergic G-protein-coupled receptor. | 2008 Jul 24 |
|
| Preservation of the positive lusitropic effect of beta-adrenoceptors stimulation in diabetic cardiomyopathy. | 2008 Oct |
|
| Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors. | 2009 |
|
| [Role of serotonin receptors in vascular tone in the pithed rat]. | 2009 Dec |
|
| G-protein-coupled receptor structure: what can we learn? | 2009 Feb 24 |
|
| X-ray structure breakthroughs in the GPCR transmembrane region. | 2009 Jul 1 |
|
| Can [I]-Iodocyanopindolol Label β(3)-Adrenoceptors in Rat Urinary Bladder? | 2010 |
|
| Influence of beta2-adrenoceptor gene polymorphisms on beta2-adrenoceptor expression in human lung. | 2010 Apr |
|
| Tissue functions mediated by beta(3)-adrenoceptors-findings and challenges. | 2010 Aug |
|
| Structural insights into conformational stability of wild-type and mutant beta1-adrenergic receptor. | 2010 Jul 21 |
|
| Forced unbinding of GPR17 ligands from wild type and R255I mutant receptor models through a computational approach. | 2010 Mar 16 |
|
| A full pharmacological analysis of the three turkey β-adrenoceptors and comparison with the human β-adrenoceptors. | 2010 Nov 30 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:30:35 UTC 2023
by
admin
on
Sat Dec 16 08:30:35 UTC 2023
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| Record UNII |
4K0SD5SNFS
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| Record Status |
Validated (UNII)
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| Record Version |
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81608-27-7
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107752
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Cyanopindolol
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DTXSID801002083
Created by
admin on Sat Dec 16 08:30:35 UTC 2023 , Edited by admin on Sat Dec 16 08:30:35 UTC 2023
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4K0SD5SNFS
Created by
admin on Sat Dec 16 08:30:35 UTC 2023 , Edited by admin on Sat Dec 16 08:30:35 UTC 2023
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PRIMARY |