Aplitabart

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National Institutes of Health Divider Arrow

NCATS

Investigational

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 08:18:23 GMT 2025` Edited by `admin` on `Wed Apr 02 08:18:23 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGM
Sequence Type	COMPLETE
Record UNII	4JZ0485VXV
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Aplitabart

Official Name

English

IGM-8444

Preferred Name

English

Immunoglobulin M, anti-(human death receptor 5) (human-Mus musculus clone IGM-8444 ?-chain), disulfide with human-Mus musculus clone IGM-8444 ?-chain, dimer, pentamer with immunoglobulin [102????????????????????-alanine] human-Mus musculus clone IGM-8444

Common Name

English

IGM8444

Code

English

IGM 8444 [WHO-DD]

Common Name

English

immunoglobulin M-kappa cyclic pentamer bisdisulfide with the JCHAIN (joining chain of multimeric IgA and IgM), anti-[Homo sapiens TNFRSF10B (TNF receptor superfamily member 10B, death receptor 5, DR5, TNF-related apoptosis-inducing ligand TRAIL receptor

Common Name

English

aplitabart [INN]

Common Name

English

Code System Code Type Description

FDA UNII

4JZ0485VXV

Created by admin on Wed Apr 02 08:18:23 GMT 2025 , Edited by admin on Wed Apr 02 08:18:23 GMT 2025

PRIMARY

SMS_ID

300000050416

Created by admin on Wed Apr 02 08:18:23 GMT 2025 , Edited by admin on Wed Apr 02 08:18:23 GMT 2025

PRIMARY

INN

12990

Created by admin on Wed Apr 02 08:18:23 GMT 2025 , Edited by admin on Wed Apr 02 08:18:23 GMT 2025

PRIMARY

NCI_THESAURUS

C176625

Created by admin on Wed Apr 02 08:18:23 GMT 2025 , Edited by admin on Wed Apr 02 08:18:23 GMT 2025

PRIMARY

CAS

2796349-94-3

Created by admin on Wed Apr 02 08:18:23 GMT 2025 , Edited by admin on Wed Apr 02 08:18:23 GMT 2025

PRIMARY

From	To
8_571	9_571
6_571	7_571
4_571	5_571
2_571	3_571
20_213	10_207
19_213	9_207
18_213	8_207
17_213	7_207
16_213	6_207
5_207	15_213
4_207	14_213
3_207	13_213
2_207	12_213
1_207	11_213

Glycosylation Link Type	Site
N	1_165
N	1_328
N	1_391
N	1_398
N	1_559
N	2_165
N	2_328
N	2_391
N	2_398
N	2_559
N	3_165
N	3_328
N	3_391
N	3_398
N	3_559
N	4_165
N	4_328
N	4_391
N	4_398
N	4_559
N	21_49
N	5_165
N	5_328
N	5_391
N	5_398
N	5_559
O	1_170
O	1_171
O	1_172
O	2_170
O	2_171
O	2_172
O	3_170
O	3_171
O	3_172
O	4_170
O	4_171
O	4_172
O	5_170
O	5_171
O	5_172

Related Record Type Details


					H8QG06RS7R

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 10B

TARGET -> AGONIST

Amount:

Related Record Type Details


					4JZ0485VXV

ACTIVE MOIETY

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL