IMIDAZOLE SALICYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H6O3.C3H4N2
Molecular Weight	206.198
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

N1C=CN=C1.OC(=O)C2=CC=CC=C2O

InChI

InChIKey=XCHHJFVNQPPLJK-UHFFFAOYSA-N

InChI=1S/C7H6O3.C3H4N2/c8-6-4-2-1-3-5(6)7(9)10;1-2-5-3-4-1/h1-4,8H,(H,9,10);1-3H,(H,4,5)

HIDE SMILES / InChI

Molecular Formula	C7H6O3
Molecular Weight	138.1207
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C3H4N2
Molecular Weight	68.0773
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/3273866 | https://www.ncbi.nlm.nih.gov/pubmed/2212452 | https://www.ncbi.nlm.nih.gov/pubmed/8301062

Imidazole salicylate (also known as ITF-182), a nonsteroidal anti-inflammatory drug (NSAID) that inhibits Tromboxane A2 synthesis, without interfering with cyclo-oxygenase pathway and possesses the limited inhibitory effects on prostaglandin synthesis. Imidazole salicylate can be used for the treatment of osteoarthrosis and musculoskeletal trauma. In addition, it can be given to patients with decompensated cirrhosis without risk of inhibiting kidney prostaglandin synthesis. Imidazole salicylate was characterized by good gastric tolerability and could be assigned for treatment of rheumatic diseases in the elderly. The drug also can be safely used in aspirin-sensitive patients.

Approval Year

PubMed

Title	Date	PubMed
Imidazole salicylate in the treatment of osteoarthrosis and musculoskeletal trauma: a postmarketing survey.	1988	3273866
Imidazole salicylate versus piroxicam in the treatment of arthrosis in elderly patients. A double-blind clinical and endoscopic trial.	1990 Sep	2212452
Blood binding of selezen (imidazole salicylate) in man.	1991 Jun	1869346
Effects of imidazole-salicylate on renal function and the diuretic action of furosemide in cirrhotic patients with ascites.	1993 Sep	8301062

Sample Use Guides

In Vivo Use Guide

Imidazole salicylate (750 mg t.i.d.) was compared with ibuprofen (400 mg t.i.d.) in a 60-day double-blind parallel group clinical trial in 31 patients with osteoarthritis

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 16:22:01 GMT 2023` Edited by `admin` on `Fri Dec 15 16:22:01 GMT 2023`
Record UNII	4JVD4X01MJ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IMIDAZOLE SALICYLATE

Official Name

English

IMIDAZOLE SALICYLATE [MART.]

Common Name

English

imidazole salicylate [INN]

Common Name

English

IMIDAZOLE-2-HYDROXYBENZOATE

Systematic Name

English

Imidazole salicylate [WHO-DD]

Common Name

English

IMIDAZOLE SALICYLATE [MI]

Common Name

English

SALICYLIC ACID, COMPOUND WITH IMIDAZOLE (1:1)

Common Name

English

SELEZEN

Brand Name

English

Classification Tree Code System Code

WHO-ATC

N02BA16