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Details

Stereochemistry ACHIRAL
Molecular Formula C7H6O3.C3H4N2
Molecular Weight 206.1984
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IMIDAZOLE SALICYLATE

SMILES

c1ccc(c(c1)C(=O)O)O.c1cnc[nH]1

InChI

InChIKey=XCHHJFVNQPPLJK-UHFFFAOYSA-N
InChI=1S/C7H6O3.C3H4N2/c8-6-4-2-1-3-5(6)7(9)10;1-2-5-3-4-1/h1-4,8H,(H,9,10);1-3H,(H,4,5)

HIDE SMILES / InChI

Molecular Formula C3H4N2
Molecular Weight 68.0774
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Molecular Formula C7H6O3
Molecular Weight 138.121
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Imidazole salicylate (also known as ITF-182), a nonsteroidal anti-inflammatory drug (NSAID) that inhibits Tromboxane A2 synthesis, without interfering with cyclo-oxygenase pathway and possesses the limited inhibitory effects on prostaglandin synthesis. Imidazole salicylate can be used for the treatment of osteoarthrosis and musculoskeletal trauma. In addition, it can be given to patients with decompensated cirrhosis without risk of inhibiting kidney prostaglandin synthesis. Imidazole salicylate was characterized by good gastric tolerability and could be assigned for treatment of rheumatic diseases in the elderly. The drug also can be safely used in aspirin-sensitive patients.

Approval Year

PubMed

PubMed

TitleDatePubMed
Imidazole salicylate in the treatment of osteoarthrosis and musculoskeletal trauma: a postmarketing survey.
1988
Imidazole salicylate versus piroxicam in the treatment of arthrosis in elderly patients. A double-blind clinical and endoscopic trial.
1990 Sep
Blood binding of selezen (imidazole salicylate) in man.
1991 Jun
Double-blind randomized clinical trial on imidazole salicylate vs ibuprofen in osteoarthritis.
1991 May
Effects of imidazole-salicylate on renal function and the diuretic action of furosemide in cirrhotic patients with ascites.
1993 Sep
Tolerability of imidazole salycilate in aspirin-sensitive patients.
1995 Sep-Oct

Sample Use Guides

Imidazole salicylate (750 mg t.i.d.) was compared with ibuprofen (400 mg t.i.d.) in a 60-day double-blind parallel group clinical trial in 31 patients with osteoarthritis
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Sat Jun 26 00:20:23 UTC 2021
Edited
by admin
on Sat Jun 26 00:20:23 UTC 2021
Record UNII
4JVD4X01MJ
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IMIDAZOLE SALICYLATE
INN   MART.   MI   WHO-DD  
INN  
Official Name English
IMIDAZOLE SALICYLATE [MART.]
Common Name English
IMIDAZOLE SALICYLATE [INN]
Common Name English
IMIDAZOLE-2-HYDROXYBENZOATE
Systematic Name English
IMIDAZOLE SALICYLATE [MI]
Common Name English
SALICYLIC ACID, COMPOUND WITH IMIDAZOLE (1:1)
Common Name English
IMIDAZOLE SALICYLATE [WHO-DD]
Common Name English
SELEZEN
Brand Name English
Classification Tree Code System Code
WHO-ATC N02BA16
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
NCI_THESAURUS C257
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
WHO-VATC QN02BA16
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
Code System Code Type Description
ChEMBL
CHEMBL2104788
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY
DRUG BANK
DB13860
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY
CAS
36364-49-5
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY
PUBCHEM
37425
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY
MESH
C043292
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY
NCI_THESAURUS
C65894
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY
EVMPD
SUB08145MIG
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY
FDA UNII
4JVD4X01MJ
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY
MERCK INDEX
M6224
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY Merck Index
INN
5485
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY
RXCUI
27438
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY RxNorm
EPA CompTox
36364-49-5
Created by admin on Sat Jun 26 00:20:23 UTC 2021 , Edited by admin on Sat Jun 26 00:20:23 UTC 2021
PRIMARY
Related Record Type Details
PARENT -> SALT/SOLVATE