Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | 2Cl.Pb |
| Molecular Weight | 278.1 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Cl-].[Cl-].[PbH2++]
InChI
InChIKey=LIGWDQJYFXTLPL-UHFFFAOYSA-L
InChI=1S/2ClH.Pb.2H/h2*1H;;;/q;;+2;;/p-2
| Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Pb |
| Molecular Weight | 207.2 |
| Charge | 2 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/27486358http://nj.gov/health/eoh/rtkweb/documents/fs/1107.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2535340FRITZ BISCHOFF, L. C. MAXWELL, RICHARD D. EVANS, and FRANKLIN R. NUZUM. Journal of Pharmacology and Experimental Therapeutics September 1928, 34 (1) 85-109, retrived from http://jpet.aspetjournals.org/content/34/1/85 | https://www.ncbi.nlm.nih.gov/pubmed/14038324https://www.ncbi.nlm.nih.gov/pubmed/14038324https://www.ncbi.nlm.nih.gov/pubmed/20340530 | https://www.ncbi.nlm.nih.gov/pubmed/18935555Curator's Comment: description was created based on several sources, including
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/lead-public_508.pdf
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27486358http://nj.gov/health/eoh/rtkweb/documents/fs/1107.pdfhttps://www.ncbi.nlm.nih.gov/pubmed/2535340FRITZ BISCHOFF, L. C. MAXWELL, RICHARD D. EVANS, and FRANKLIN R. NUZUM. Journal of Pharmacology and Experimental Therapeutics September 1928, 34 (1) 85-109, retrived from http://jpet.aspetjournals.org/content/34/1/85 | https://www.ncbi.nlm.nih.gov/pubmed/14038324https://www.ncbi.nlm.nih.gov/pubmed/14038324https://www.ncbi.nlm.nih.gov/pubmed/20340530 | https://www.ncbi.nlm.nih.gov/pubmed/18935555
Curator's Comment: description was created based on several sources, including
https://ntp.niehs.nih.gov/ntp/newhomeroc/roc11/lead-public_508.pdf
There is no information about biological application only a few articles about pharmacological application of lead fluoride, that this substance was investigated for topical dental caries.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The effect of topical applications of lead fluoride on dental caries. | 1947 Dec |
|
| The effect of topically applied fluorides on dental caries experience; report of findings with two, four and six applications of sodium fluoride and of lead fluoride. | 1947 Oct 10 |
|
| [Contribution to the study on allergy among workers exposed to lead oxide and lead sulfide]. | 1961 Jul-Dec |
|
| Microbial uptake of lead. | 1972 Jun 23 |
|
| Interaction of lead and bacterial lipids. | 1975 May |
|
| Subacute effects of lead-oxide fumes in demolition workers. | 1977 Jan 8 |
|
| Abiotic factors affecting the toxicity of lead to fungi. | 1979 Sep |
|
| Interconnection of activation volumes and activation enthalpies in cubic lead fluoride doped with alkali-metal cations. | 1985 Jun 15 |
|
| Lead oxide emissions--a case history. | 1986 |
|
| Mutagenic effects of lead (II) bromide. | 1989 Dec |
|
| [The late effects of exposure to lead fluoride]. | 1992 Mar |
|
| Structural Chemistry of Poly(ethylene glycol) Complexes of Lead(II) Nitrate and Lead(II) Bromide. | 1996 Nov 20 |
|
| [Lead in the blood and protoporphyrin levels in erythrocytes in glass workers exposed to lead]. | 1997 Dec |
|
| Maternal low-level lead exposure reduces the expression of PSA-NCAM and the activity of sialyltransferase in the hippocampi of neonatal rat pups. | 2008 Jul |
|
| The oxidative damage and inflammatory response induced by lead sulfide nanoparticles in rat lung. | 2013 Oct |
|
| Autophagy plays a protective role in cell death of osteoblasts exposure to lead chloride. | 2015 Dec 3 |
|
| Probit analysis of comparative assays on toxicities of lead chloride and lead acetate to in vitro cultured human umbilical cord blood lymphocytes. | 2015 Mar |
|
| Rat Testis Damage Caused by Lead Sulfide Nanoparticles After Oral Exposure. | 2016 Mar |
|
| Highly luminescent nanoscale quasi-2D layered lead bromide perovskites with tunable emissions. | 2016 Mar 11 |
Sample Use Guides
It was investigated the cytotoxicity of lead chloride in vitro cultured lymphocytes from human umbilical cord blood, using four monitoring methods namely, trypan blue staining, acridine orange/ethidium bromide staining, 3-[4,5-dimethylthiazol-2-yl] 2,5-diphenyl tetrazolium bromide (MTT) and neutral red uptake assays; lead genotoxicity to lymphocytes was monitored by comet assay. The MIC value in each method was invariably 300 mg/L for PbCl2. Lethal concentration25 (LC25) values were almost in an agreeable range: 691.83 to 831.76 mg/L; LC50 values in each method were almost in the range: 1174.9 to 1348.9 mg/L; LC100 values were in the range: 3000 to 3300 mg/L, for lead chloride. The comet assay also indicated that the LC100 values were 3300 mg/L lead chloride. Thus, both cytotoxicity and genotoxicity were recorded at 3300 mg/L lead chloride with lymphocytes.
| Substance Class |
Chemical
Created
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| Record UNII |
4IL61GN3YI
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| Record Status |
Validated (UNII)
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| Record Version |
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LEAD(II) CHLORIDE
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