TADNERSEN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Tue Apr 01 22:39:37 GMT 2025` Edited by `admin` on `Tue Apr 01 22:39:37 GMT 2025`
Record UNII	4GJV2Y7RD9
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

BIIB-078

Preferred Name

English

TADNERSEN SODIUM

Common Name

English

RNA, ((2'-O-(2-METHOXYETHYL))G-SP-(2'-O-(2-METHOXYETHYL))M5C-(2'-O-(2-METHOXYETHYL))M5C-(2'-O-(2-METHOXYETHYL))M5C-SP-M5DC-SP-DT-SP-DA-SP-DG-SP-M5DC-SP-DG-SP-M5DC-SP-DG-SP-(2'-O-(2-METHOXYETHYL))M5C-(2'-O-(2-METHOXYETHYL))G-(2'-O-(2-METHOXYETHYL))A-(2'-O

Common Name

English

BIIB078

Code

English

Code System Code Type Description

CAS

2328213-31-4

Created by admin on Tue Apr 01 22:39:37 GMT 2025 , Edited by admin on Tue Apr 01 22:39:37 GMT 2025

PRIMARY

FDA UNII

4GJV2Y7RD9

Created by admin on Tue Apr 01 22:39:37 GMT 2025 , Edited by admin on Tue Apr 01 22:39:37 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_5-1_12	8 / 18
2'-O-Methoxyethyl ribose	1_1-1_4;1_13-1_18	10 / 18

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2;1_5-1_13;1_17-1_18	12 / 17
	1_3-1_4;1_14-1_16	5 / 17

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_17]	SITE_SPECIFIC			THYMINE	QR26YLT7LT
NUCLEOSIDE BASE SUBSTITUTION	[1_2] [1_3] [1_4] [1_5] [1_9] [1_11] [1_13] [1_16]	SITE_SPECIFIC			5-METHYLCYTOSINE	6R795CQT4H