Zimislecel

Approval Year

Substance Class	Structurally Diverse Created by `admin` on `Sat Dec 16 18:52:35 UTC 2023` Edited by `admin` on `Sat Dec 16 18:52:35 UTC 2023`
Source Materials Class	ORGANISM
Source Materials Type	ALLOGENIC HUMAN
Source Materials Parent	`G0T704E6Z3` HOMO SAPIENS WHOLE
Part	Embryo
Fraction Name	STEM CELLS
Record UNII	4FBM3KR723
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Zimislecel

Official Name

English

allogenic pancreatic islets derived from a human embryonic stem cell (ESC) line. The initial ESCs are positive for OCT4A (>70%) and stage-specific embryonic antigen-4 (SSEA4; >90%). The pancreatic islets are differentiated from the ESCs in five stages: (

Common Name

English

zimislecel [INN]

Common Name

English

Code System Code Type Description

INN

12529

Created by admin on Sat Dec 16 18:52:35 UTC 2023 , Edited by admin on Sat Dec 16 18:52:35 UTC 2023

PRIMARY

FDA UNII

4FBM3KR723

Created by admin on Sat Dec 16 18:52:35 UTC 2023 , Edited by admin on Sat Dec 16 18:52:35 UTC 2023

PRIMARY

Related Record Type Details


					4FBM3KR723

Zimislecel

ACTIVE MOIETY

Amount:

Agent Modifications

Modification Process	Modification Role	Modification Type	Fragment Name	Fragment ID
CULTURE	late pancreatic progenitor induction	BIOLOGICAL	PHORBOL 12,13-DIBUTYRATE	67MX82CL58
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	STAUROSPORINE	H88EPA0A3N
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	Thiazovivin	7268XHE3P7
CULTURE	early pancreatic progenitor induction	BIOLOGICAL	SANT 1	GYK6BKF2M2
CULTURED	late pancreatic progenitor induction	BIOLOGICAL	PALIFERMIN	QMS40680K6
CULTURE	early pancreatic progenitor induction	BIOLOGICAL	TRETINOIN	5688UTC01R
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	Gamma-Secretase inhibitor XXI	W6YYB9B856
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	ZINC SULFATE, UNSPECIFIED FORM	89DS0H96TB
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	NALTREXONE	5S6W795CQM
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	NVP-TNKS-656	YE73635MQC
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	3-DEAZANEPLANOCIN	544SH4020S
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	SANT 1	GYK6BKF2M2
CULTURE	early pancreatic progenitor induction	BIOLOGICAL	DMH-1	BVR5X3H6XM
CULTURE	late pancreatic progenitor induction	BIOLOGICAL	SANT 1	GYK6BKF2M2
CULTURE	Definitive endoderm induction	BIOLOGICAL	ACTIVIN A	8JH1HY3MS5
CULTURE	Definitive endoderm induction	BIOLOGICAL	LADUVIGLUSIB	234CMT4GK4
CULTURE	early pancreatic progenitor induction	BIOLOGICAL	ACTIVIN A	8JH1HY3MS5
CULTURE	early pancreatic progenitor induction	BIOLOGICAL	Thiazovivin	7268XHE3P7
CULTURE	late pancreatic progenitor induction	BIOLOGICAL	ACTIVIN A	8JH1HY3MS5
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	RepSox	JT8ZW3H2ST
CULTURE	Gut tube formation	BIOLOGICAL	PALIFERMIN	QMS40680K6
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	TRETINOIN	5688UTC01R
CULTURE	late pancreatic progenitor induction	BIOLOGICAL	TRETINOIN	5688UTC01R
CULTURE	early pancreatic progenitor induction	BIOLOGICAL	PALIFERMIN	QMS40680K6
CULTURE	late pancreatic progenitor induction	BIOLOGICAL	Thiazovivin	7268XHE3P7
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	PHORBOL 12,13-DIBUTYRATE	67MX82CL58
CULTURE	pancreatic endocrine induction	DIFFERENTIATION	BETACELLULIN	HKD5QF8HP2