Details
Stereochemistry | MIXED |
Molecular Formula | C12H22O6 |
Molecular Weight | 262.2995 |
Optical Activity | UNSPECIFIED |
Defined Stereocenters | 0 / 2 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
C(COCCOCC1CO1)OCCOCC2CO2
InChI
InChIKey=UMILHIMHKXVDGH-UHFFFAOYSA-N
InChI=1S/C12H22O6/c1(13-3-5-15-7-11-9-17-11)2-14-4-6-16-8-12-10-18-12/h11-12H,1-10H2
Molecular Formula | C12H22O6 |
Molecular Weight | 262.2995 |
Charge | 0 |
Count |
|
Stereochemistry | MIXED |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 2 |
E/Z Centers | 0 |
Optical Activity | UNSPECIFIED |
Etoglucid is a cytotoxic drug used as neoplastic agent for the treatment of malignant tumors. Etoglucid was synthesized by reacting a diol with two equivalents of an alkyl chloride. This alkylating agent is commonly used in Europe but is not available in the United States. It is readily diffusible into the cerebral fluid into cerebrospinal fluid but has a metabolic half-life of only 10 to 15 min. It has been shown in animal experiments to be rapidly destroyed in the liver and thus possibly less damaging to the bone-marrow. Only the polymorphonuclear leucocytes being greatly reduced. The blood returned to normal in two to three weeks, and no other important toxic changes were observed.
Approval Year
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14120811
75 to 100 mg/kg of body weight
Route of Administration:
Intra-arterial
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:17:35 GMT 2023
by
admin
on
Fri Dec 15 16:17:35 GMT 2023
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Record UNII |
4F9KUA0T4D
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Record Status |
Validated (UNII)
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WHO-ATC |
L01AG01
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NCI_THESAURUS |
C1590
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WHO-VATC |
QL01AG01
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D005009
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C489
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100000082105
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DTXSID80862800
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3213
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4132
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80439
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1579
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SUB07326MIG
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Etoglucid
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1954-28-5
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16058
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CHEMBL460287
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m5195
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4F9KUA0T4D
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217-784-7
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DB13339
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Related Record | Type | Details | ||
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ACTIVE MOIETY |