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Details

Stereochemistry MIXED
Molecular Formula C12H22O6
Molecular Weight 262.2995
Optical Activity UNSPECIFIED
Defined Stereocenters 0 / 2
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ETOGLUCID

SMILES

C(COCCOCC1CO1)OCCOCC2CO2

InChI

InChIKey=UMILHIMHKXVDGH-UHFFFAOYSA-N
InChI=1S/C12H22O6/c1(13-3-5-15-7-11-9-17-11)2-14-4-6-16-8-12-10-18-12/h11-12H,1-10H2

HIDE SMILES / InChI

Molecular Formula C12H22O6
Molecular Weight 262.2995
Charge 0
Count
MOL RATIO 1 MOL RATIO (average)
Stereochemistry MIXED
Additional Stereochemistry No
Defined Stereocenters 0 / 2
E/Z Centers 0
Optical Activity UNSPECIFIED

Description

Etoglucid is a cytotoxic drug used as neoplastic agent for the treatment of malignant tumors. Etoglucid was synthesized by reacting a diol with two equivalents of an alkyl chloride. This alkylating agent is commonly used in Europe but is not available in the United States. It is readily diffusible into the cerebral fluid into cerebrospinal fluid but has a metabolic half-life of only 10 to 15 min. It has been shown in animal experiments to be rapidly destroyed in the liver and thus possibly less damaging to the bone-marrow. Only the polymorphonuclear leucocytes being greatly reduced. The blood returned to normal in two to three weeks, and no other important toxic changes were observed.

Approval Year

Sample Use Guides

In Vivo Use Guide
75 to 100 mg/kg of body weight
Route of Administration: Intra-arterial
Substance Class Chemical
Record UNII
4F9KUA0T4D
Record Status Validated (UNII)
Record Version