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Details

Stereochemistry ACHIRAL
Molecular Formula C14H13NO4
Molecular Weight 259.2573
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of SKIMMIANINE

SMILES

COC1=C(OC)C2=C(C=C1)C(OC)=C3C=COC3=N2

InChI

InChIKey=SLSIBLKBHNKZTB-UHFFFAOYSA-N
InChI=1S/C14H13NO4/c1-16-10-5-4-8-11(13(10)18-3)15-14-9(6-7-19-14)12(8)17-2/h4-7H,1-3H3

HIDE SMILES / InChI
Molecular Formula C14H13NO4
Molecular Weight 259.2573
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description

Skimmianine is a newly discovered strong acetylcholinesterase (AChE) inhibitor, which can be used as promising candidate for L. braziliensis due to its potent immunomodulatory activity. In addition, because skimmianine has multi-targeted mechanism of action, it can be suggested for therapeutic efficacy in various inflammatory diseases.

Approval Year

Unknown
139594
Targets

Targets

Primary TargetPharmacologyConditionPotency
Inhibitor
8297
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
Basic research
Unknown

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides.
2005 Nov 1
Zanthoxylum capense constituents with antimycobacterial activity against Mycobacterium tuberculosis in vitro and ex vivo within human macrophages.
2013 Mar 7

Sample Use Guides

In Vivo Use Guide
at a dose of 5.0 mg/kg body weight
Route of Administration: Unknown
In Vitro Use Guide
The in vitro 50% inhibitory concentrations of y-fagarine, acidified extract, ethanol extract, skimmianine and alkaloid extract against promastigotes were determined as 8.7, 9.4, 10.9, 25.7 and 25.8 microg/mL respectively.
Substance Class Chemical
Created
by admin
on Fri Dec 15 20:15:39 GMT 2023
Edited
by admin
on Fri Dec 15 20:15:39 GMT 2023
Record UNII
4E1KLC380B
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
SKIMMIANINE
MI  
Common Name English
NSC-217986
Code English
SKIMMIAMINE
Common Name English
SKIMMIANINE [MI]
Common Name English
SKIMMIANIN
Common Name English
CHLOROXYLONINE
Common Name English
NSC-94654
Code English
FURO(2,3-B)QUINOLINE, 4,7,8-TRIMETHOXY-
Systematic Name English
.BETA.-FAGARINE
Common Name English
Code System Code Type Description
MERCK INDEX
m9969
Created by admin on Fri Dec 15 20:15:40 GMT 2023 , Edited by admin on Fri Dec 15 20:15:40 GMT 2023
PRIMARY Merck Index
WIKIPEDIA
Skimmianine
Created by admin on Fri Dec 15 20:15:40 GMT 2023 , Edited by admin on Fri Dec 15 20:15:40 GMT 2023
PRIMARY
PUBCHEM
6760
Created by admin on Fri Dec 15 20:15:40 GMT 2023 , Edited by admin on Fri Dec 15 20:15:40 GMT 2023
PRIMARY
CAS
83-95-4
Created by admin on Fri Dec 15 20:15:40 GMT 2023 , Edited by admin on Fri Dec 15 20:15:40 GMT 2023
PRIMARY
MESH
C035932
Created by admin on Fri Dec 15 20:15:40 GMT 2023 , Edited by admin on Fri Dec 15 20:15:40 GMT 2023
PRIMARY
FDA UNII
4E1KLC380B
Created by admin on Fri Dec 15 20:15:40 GMT 2023 , Edited by admin on Fri Dec 15 20:15:40 GMT 2023
PRIMARY
NSC
94654
Created by admin on Fri Dec 15 20:15:40 GMT 2023 , Edited by admin on Fri Dec 15 20:15:40 GMT 2023
PRIMARY
EPA CompTox
DTXSID90232116
Created by admin on Fri Dec 15 20:15:40 GMT 2023 , Edited by admin on Fri Dec 15 20:15:40 GMT 2023
PRIMARY
NSC
217986
Created by admin on Fri Dec 15 20:15:40 GMT 2023 , Edited by admin on Fri Dec 15 20:15:40 GMT 2023
PRIMARY
NIH
NCATS
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