Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H24N2O3 |
| Molecular Weight | 340.4162 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@]1(C[C@@H]2CC[N@]1C[C@]2(O)C=C)[C@H](O)C3=C4C=C(OC)C=CC4=NC=C3
InChI
InChIKey=BSRUJCFCZKMFMB-YGHPHNMRSA-N
InChI=1S/C20H24N2O3/c1-3-20(24)12-22-9-7-13(20)10-18(22)19(23)15-6-8-21-17-5-4-14(25-2)11-16(15)17/h3-6,8,11,13,18-19,23-24H,1,7,9-10,12H2,2H3/t13-,18-,19+,20+/m0/s1
| Molecular Formula | C20H24N2O3 |
| Molecular Weight | 340.4162 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4? | 2002 Dec |
|
| Metabolism and elimination of quinine in healthy volunteers. | 2003 Sep |
|
| High-performance liquid chromatographic method for the determination of quinine and 3-hydroxyquinine in blood samples dried on filter paper. | 2003 Sep 25 |
|
| Simultaneous liquid chromatographic analysis of ritonavir, quinine and 3-hydroxyquinine in human plasma. | 2009 Feb 1 |
|
| Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans. | 2010 Jun |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 07:32:37 UTC 2023
by
admin
on
Sat Dec 16 07:32:37 UTC 2023
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| Record UNII |
4D7695509M
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| Record Status |
Validated (UNII)
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| Record Version |
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17685
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157225
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DTXSID901316798
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4D7695509M
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58234
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78549-61-8
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> METABOLITE LESS ACTIVE |
Quinine is metabolized almost exclusively via hepatic oxidative cytochrome P450 (CYP) pathways. In vitro studies using human liver microsomes and recombinant P450 enzymes have shown that quinine is metabolized mainly by CYP3A4. Depending on the in vitro experimental conditions, other enzymes, including CYP1A2, CYP2C8, CYP2C9, CYP2C19, CYP2D6, and CYP2E1 were shown to have some role in the metabolism of quinine.
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