Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H24N2O3 |
| Molecular Weight | 340.4162 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC2=C(C=CN=C2C=C1)[C@@H](O)[C@@H]3C[C@@H]4CC[N@]3C[C@]4(O)C=C
InChI
InChIKey=BSRUJCFCZKMFMB-YGHPHNMRSA-N
InChI=1S/C20H24N2O3/c1-3-20(24)12-22-9-7-13(20)10-18(22)19(23)15-6-8-21-17-5-4-14(25-2)11-16(15)17/h3-6,8,11,13,18-19,23-24H,1,7,9-10,12H2,2H3/t13-,18-,19+,20+/m0/s1
| Molecular Formula | C20H24N2O3 |
| Molecular Weight | 340.4162 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of Plasmodium falciparum infection on the pharmacokinetics of quinine and its metabolites in pregnant and non-pregnant Sudanese women. | 2010-12 |
|
| Genetic variations in ABCB1 and CYP3A5 as well as sex influence quinine disposition among Ugandans. | 2010-06 |
|
| Pharmacokinetic interactions between ritonavir and quinine in healthy volunteers following concurrent administration. | 2010-03 |
|
| Simultaneous liquid chromatographic analysis of ritonavir, quinine and 3-hydroxyquinine in human plasma. | 2009-02-01 |
|
| Variable inhibitory effect of different brands of commercial herbal supplements on human cytochrome P-450 CYP3A4. | 2009 |
|
| Pharmacokinetics and clinical efficacy of midazolam in children with severe malaria and convulsions. | 2008-10 |
|
| Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers. | 2007-02 |
|
| Quinine distribution in pregnant mice with Plasmodium berghei malaria. | 2006-07 |
|
| Ketoconazole increases plasma concentrations of antimalarial mefloquine in healthy human volunteers. | 2005-06 |
|
| High-performance liquid chromatographic method for the determination of quinine and 3-hydroxyquinine in blood samples dried on filter paper. | 2003-09-25 |
|
| Metabolism and elimination of quinine in healthy volunteers. | 2003-09 |
|
| Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man. | 2003-05 |
|
| Is quinine a suitable probe to assess the hepatic drug-metabolizing enzyme CYP3A4? | 2002-12 |
|
| Quinine pharmacokinetics in chronic haemodialysis patients. | 2002-12 |
|
| Enzyme kinetics for the formation of 3-hydroxyquinine and three new metabolites of quinine in vitro; 3-hydroxylation by CYP3A4 is indeed the major metabolic pathway. | 2002-12 |
|
| Effects of cigarette smoking on quinine pharmacokinetics in malaria. | 2002-08 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 21:41:46 GMT 2025
by
admin
on
Mon Mar 31 21:41:46 GMT 2025
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| Record UNII |
4D7695509M
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| Record Status |
Validated (UNII)
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| Record Version |
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PARENT -> METABOLITE LESS ACTIVE |
