Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H4Cl6 |
| Molecular Weight | 360.878 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC(C2=CC(Cl)=C(Cl)C=C2)=C(Cl)C(Cl)=C1Cl
InChI
InChIKey=LCXMEXLGMKFLQO-UHFFFAOYSA-N
InChI=1S/C12H4Cl6/c13-7-2-1-5(3-8(7)14)6-4-9(15)11(17)12(18)10(6)16/h1-4H
| Molecular Formula | C12H4Cl6 |
| Molecular Weight | 360.878 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: greater insight into species differences in toxic potency of polychlorinated dibenzo-p-dioxin, dibenzofuran, and biphenyl congeners. | 1999 Aug 15 |
|
| Dose-response relationships for induction of CYP1A1 and CYP1A2 enzyme activity in liver, lung, and skin in female mice following subchronic exposure to polychlorinated biphenyls. | 2000 Sep 15 |
|
| Application of the ethoxyresorufin-O-deethylase (EROD) assay to mixtures of halogenated aromatic compounds. | 2001 |
|
| Brominated dioxin-like compounds: in vitro assessment in comparison to classical dioxin-like compounds and other polyaromatic compounds. | 2003 Sep |
|
| Interaction between halogenated aromatic compounds in the Ah receptor signal transduction pathway. | 2004 Oct |
|
| Inhibition of human and rat CYP1A2 by TCDD and dioxin-like chemicals. | 2005 Apr |
|
| Induction of cytochrome P450 1A5 mRNA, protein and enzymatic activities by dioxin-like compounds, and congener-specific metabolism and sequestration in the liver of wild jungle crow (Corvus macrorhynchos) from Tokyo, Japan. | 2005 Dec |
|
| Cytochrome P450 1A4 and 1A5 in common cormorant (Phalacrocorax carbo): evolutionary relationships and functional implications associated with dioxin and related compounds. | 2006 Aug |
|
| Selected polychlorobiphenyls congeners bind to estrogen receptor alpha in human umbilical vascular endothelial (HUVE) cells modulating angiogenesis. | 2006 Jan 20 |
|
| Mechanistic study of polychlorinated biphenyl 126-induced CYP11B1 and CYP11B2 up-regulation. | 2006 Mar |
|
| Determination of in vitro relative potency (REP) values for mono-ortho polychlorinated biphenyls after purification with active charcoal. | 2006 Sep 10 |
|
| The flame retardants, polybrominated diphenyl ethers, are pregnane X receptor activators. | 2007 May |
|
| Screening of 397 chemicals and development of a quantitative structure--activity relationship model for androgen receptor antagonism. | 2008 Apr |
|
| Pharmacologic profiling of human and rat cytochrome P450 1A1 and 1A2 induction and competition. | 2008 Dec |
|
| Relative potency based on hepatic enzyme induction predicts immunosuppressive effects of a mixture of PCDDS/PCDFS and PCBS. | 2008 Mar 15 |
|
| Association of organochlorine pesticides with peripheral neuropathy in patients with diabetes or impaired fasting glucose. | 2008 Nov |
|
| Transactivation potencies of Baikal seal constitutive active/androstane receptor by persistent organic pollutants and brominated flame retardants. | 2009 Aug 15 |
|
| Cutaneous symptoms such as acneform eruption and pigmentation are closely associated with blood levels of 2,3,4,7,8-penta-chlorodibenzofurans in Yusho patients, using data mining analysis. | 2009 Feb 25 |
|
| WITHDRAWN: Neurodevelopmental toxicity of prenatal polychlorinated biphenyls (PCBs) by chemical structure and activity in a birth cohort. | 2009 Jul 30 |
|
| Polychlorinated biphenyls, lead, and mercury are associated with liver disease in American adults: NHANES 2003-2004. | 2010 Dec |
|
| Developing tools for risk assessment in protected species: Relative potencies inferred from competitive binding of halogenated aromatic hydrocarbons to aryl hydrocarbon receptors from beluga (Delphinapterus leucas) and mouse. | 2010 Nov 1 |
|
| Comparison of intake and systemic relative effect potencies of dioxin-like compounds in female mice after a single oral dose. | 2013 Jul |
|
| Consensus toxicity factors for polychlorinated dibenzo-p-dioxins, dibenzofurans, and biphenyls combining in silico models and extensive in vitro screening of AhR-mediated effects in human and rodent cells. | 2015 Apr 20 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:37:20 GMT 2023
by
admin
on
Sat Dec 16 08:37:20 GMT 2023
|
| Record UNII |
4D6049M2OC
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Systematic Name | English | ||
|
Common Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
38019
Created by
admin on Sat Dec 16 08:37:20 GMT 2023 , Edited by admin on Sat Dec 16 08:37:20 GMT 2023
|
PRIMARY | |||
|
4D6049M2OC
Created by
admin on Sat Dec 16 08:37:20 GMT 2023 , Edited by admin on Sat Dec 16 08:37:20 GMT 2023
|
PRIMARY | |||
|
38380-08-4
Created by
admin on Sat Dec 16 08:37:20 GMT 2023 , Edited by admin on Sat Dec 16 08:37:20 GMT 2023
|
PRIMARY | |||
|
DTXSID0052706
Created by
admin on Sat Dec 16 08:37:20 GMT 2023 , Edited by admin on Sat Dec 16 08:37:20 GMT 2023
|
PRIMARY |