Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C8H9FN2O3 |
| Molecular Weight | 200.1671 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
FC1=CN([C@@H]2CCCO2)C(=O)NC1=O
InChI
InChIKey=WFWLQNSHRPWKFK-LURJTMIESA-N
InChI=1S/C8H9FN2O3/c9-5-4-11(6-2-1-3-14-6)8(13)10-7(5)12/h4,6H,1-3H2,(H,10,12,13)/t6-/m0/s1
| Molecular Formula | C8H9FN2O3 |
| Molecular Weight | 200.1671 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 1 / 1 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pathologic downstaging of T3-4Nx rectal cancer after chemoradiation: 5-fluorouracil vs. Tegafur. | 2001-12-01 |
|
| Phase I trial of weekly irinotecan combined with UFT as second-line treatment for advanced colorectal cancer. | 2001-12 |
|
| A comparative study of subcutaneous mastectomy with radical mastectomy. | 2001-11-20 |
|
| Fluorouracil (5FU) pharmacokinetics in 5FU prodrug formulations with a dihydropyrimidine dehydrogenase inhibitor. | 2001-11-15 |
|
| [A case of squamous cell carcinoma of the oral floor showing a complete response to oral administration of UFT]. | 2001-11 |
|
| [A complete response persisting for twelve months with the use of TS-1 in a patient with paraaortic lymph node metastasis of gastric cancer]. | 2001-11 |
|
| [A case of postoperative gastric cancer responding to adjuvant chemotherapy with TS-1--a novel oral formation of 5-fluorouracil]. | 2001-11 |
|
| [A case of breast cancer with multiple metastases effectively treated with long-term administration of docetaxel, aclarubicin and UFT]. | 2001-11 |
|
| [Dihydropyrimidine dehydrogenase activity in urothelial cancer--influence of UFT administration on DPD activity]. | 2001-11 |
|
| Plasma, intestine and tumor levels of 5-fluorouracil in mice bearing L1210 ascites tumor following oral administration of 5-fluorouracil, UFT (mixed compound of tegafur and uracil), carmofur and 5'-deoxy-5-fluorouridine. | 2001-11 |
|
| The role of UFT and the combination of UFT/leucovorin in non-small cell lung cancer. | 2001-11 |
|
| [New therapeutic options in chemotherapy of advanced colorectal cancer]. | 2001-10-15 |
|
| Early phase II study of S-1, a new oral fluoropyrimidine, for advanced non-small-cell lung cancer. | 2001-10 |
|
| Combined effects of docetaxel and fluoropyrimidines on tumor growth and expression of interleukin-6 and thymidine phosphorylase in breast cancer xenografts. | 2001-10 |
|
| [Sigmoid colon cancer with multiple liver metastasis (H3) effectively treated with CPT-11 and DSM (degradable starch microsphere) HAI therapy and intensive high dosage 5-FU HAI therapy--a case report]. | 2001-10 |
|
| [Efficacy of intraperitoneal chemotherapy for peritoneal recurrence of gastric carcinoma]. | 2001-10 |
|
| Nonsurgical treatment of hepatocellular carcinoma. | 2001-10 |
|
| [A case report of rectal cancer with liver and pulmonary metastases responding to TS-1]. | 2001-10 |
|
| [A case of remnant gastric cancer responding to neoadjuvant TS-1 therapy]. | 2001-10 |
|
| [Case report: a recurrent gastric cancer in the terminal stage, associated with obstructive jaundice which responded significantly to oral administration of TS-1]. | 2001-10 |
|
| [Complete response in a case of advanced gastric cancer with liver and intra-abdominal lymph node metastases treated by combined chemotherapy of TS-1 and CDDP]. | 2001-10 |
|
| [A pilot study of low-dose TS-1 and cisplatin combination chemotherapy for advanced gastric cancer]. | 2001-10 |
|
| [A new therapeutic approach to advanced and recurrent gastric cancer by TS-1]. | 2001-10 |
|
| [Late phase II study of S-1 in patients with advanced head and neck cancer]. | 2001-10 |
|
| Phase II study of S-1, a novel oral fluorouracil, in advanced non-small-cell lung cancer. | 2001-09-28 |
|
| Complete response achieved following administration of S-1 in a patient with adrenal gland metastasis of 5-FU-resistant gastric cancer: a case report. | 2001-09 |
|
| Oral uracil-tegafur: an alternative to intravenous 5-fluorouracil? | 2001-09 |
|
| UFT and leucovorin in first-line chemotherapy for patients with metastatic gastric cancer. An Early Clinical Studies Group (ECSG)/European Organization for Research Treatment of Cancer (EORTC) phase II trial. | 2001-09 |
|
| New drugs and combinations in the palliative treatment of colon and rectal cancer. | 2001-09 |
|
| Possible regulation of 5-fluorouracil-induced neuro- and oral toxicities by two biochemical modulators consisting of S-1, a new oral formulation of 5-fluorouracil. | 2001-08-11 |
|
| Efficacy of oral UFT plus leucovorin therapy for colon cancer with ovarian and multiple liver metastases: report of two cases. | 2001-08-10 |
|
| Simultaneous determination of F-beta-alanine and beta-alanine in plasma and urine with dual-column reversed-phase high-performance liquid chromatography. | 2001-08-05 |
|
| New options for outpatient chemotherapy--the role of oral fluoropyrimidines. | 2001-08 |
|
| [A case of nonresectable scirrhous type gastric cancer treated by hypertensive subselective chemotherapy with pharmacokinetic modulating chemotherapy]. | 2001-08 |
|
| [A case of hepatic metastasis of gastric cancer responding to TS-1, administered for two consecutive weeks and one week rest]. | 2001-08 |
|
| [Postoperative chemotherapy with a novel oral anticancer drug composed of tegafur, gimeracil and oteracil potassium to curability C scirrhus type gastric cancer]. | 2001-08 |
|
| Changes in intratumoral thymidylate synthase (TS) and dihydropyrimidine dehydrogenase (DPD) mRNA expression in colorectal and gastric cancer during continuous tegafur infusion. | 2001-08 |
|
| A phase II study of combined oral uracil and ftorafur with leucovorin for patients with squamous cell carcinoma of the head and neck. | 2001-07-15 |
|
| [A case of advanced gastric cancer that was resectable after asctic fluid had disappeared following administration of TS-1]. | 2001-07 |
|
| [A case of advanced gastric cancer with multiple liver metastases in an elderly patient that responded dramatically to UFT therapy]. | 2001-07 |
|
| [Two elderly patients with advanced gastric cancer responding to chronomodulation chemotherapy with tegafur + cisplatin + isovorin followed by oral administration of S-1]. | 2001-07 |
|
| Adjuvant chemotherapy after resection of hepatocellular carcinoma causes deterioration of long-term prognosis in cirrhotic patients: metaanalysis of three randomized controlled trials. | 2001-06-15 |
|
| Phase II trial of epirubicin, cisplatin, oral uracil and tegafur, and leucovorin in patients with advanced gastric carcinoma. | 2001-06-15 |
|
| Cutaneous metastases from gastric adenocarcinoma treated with combination chemotherapy producing complete response with long survival. | 2001-06 |
|
| Interstitial pneumonia possibly due to a novel anticancer drug, TS-1: first case report. | 2001-06 |
|
| [New oral anticancer drug, TS-1 (S-1)--from bench to clinic]. | 2001-06 |
|
| [TS-1 therapy for advanced gastric cancer]. | 2001-04 |
|
| Answering patients' needs: oral alternatives to intravenous therapy. | 2001 |
|
| [Experimental study of radiosensitizing effect of analogs of purines and pyrimidine bases in cultured HeLa cells]. | 2001 |
|
| Complete response of highly advanced gastric cancer with peritoneal dissemination after new combined chemotherapy of S-1 and low-dose cisplatin: report of a case. | 2001 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 22:53:28 GMT 2025
by
admin
on
Mon Mar 31 22:53:28 GMT 2025
|
| Record UNII |
4D5LOR404U
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Preferred Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
4D5LOR404U
Created by
admin on Mon Mar 31 22:53:28 GMT 2025 , Edited by admin on Mon Mar 31 22:53:28 GMT 2025
|
PRIMARY | |||
|
148755
Created by
admin on Mon Mar 31 22:53:28 GMT 2025 , Edited by admin on Mon Mar 31 22:53:28 GMT 2025
|
PRIMARY | |||
|
55774-30-6
Created by
admin on Mon Mar 31 22:53:28 GMT 2025 , Edited by admin on Mon Mar 31 22:53:28 GMT 2025
|
PRIMARY |