NUSINERSEN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Sat Dec 16 09:13:16 UTC 2023` Edited by `admin` on `Sat Dec 16 09:13:16 UTC 2023`
Nucleic Acid Subtype
Sequence Type	COMPLETE
Record UNII	4CHB7QQU1Q
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

NUSINERSEN SODIUM

Common Name

English

NUSINERSEN SODIUM [MI]

Common Name

English

ISIS-396443 SODIUM

Code

English

NUSINERSEN SODIUM [JAN]

Common Name

English

NUSINERSEN SODIUM [ORANGE BOOK]

Common Name

English

SPINRAZA

Brand Name

English

Nusinersen sodium [WHO-DD]

Common Name

English

RNA, (2'-0-(2-METHOXYETHYI))(P-THIO)(M5U-C-A-C-M5U-M5U-M5U-C-A-M5UA-A-M5 U-G-C-M5U-G-G), SODIUM SALT

Systematic Name

English

Classification Tree Code System Code

EU-Orphan Drug

EU/3/12/976

Created by admin on Sat Dec 16 09:13:16 UTC 2023 , Edited by admin on Sat Dec 16 09:13:16 UTC 2023

Code System Code Type Description

FDA UNII

4CHB7QQU1Q

Created by admin on Sat Dec 16 09:13:16 UTC 2023 , Edited by admin on Sat Dec 16 09:13:16 UTC 2023

PRIMARY

DRUG BANK

DBSALT002592

Created by admin on Sat Dec 16 09:13:16 UTC 2023 , Edited by admin on Sat Dec 16 09:13:16 UTC 2023

PRIMARY

MERCK INDEX

m11974

Created by admin on Sat Dec 16 09:13:16 UTC 2023 , Edited by admin on Sat Dec 16 09:13:16 UTC 2023

PRIMARY

Sugar	Site Range	Site Count
2-O-beta-hydroxy-ethoxy-methyl Ribose (Qiagen)	1_1-1_18	18 / 18

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_18	17 / 17

Related Record Type Details


					5Z9SP3X666

NUSINERSEN

PARENT -> SALT/SOLVATE

Related Record Type Details


					5Z9SP3X666

NUSINERSEN

ACTIVE MOIETY

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
BASE SUBSTITUTION	[1_2] [1_4] [1_8] [1_15]		CYTOSINE		5-METHYLCYTOSINE	6R795CQT4H

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER	CHEMICAL