Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C20H32O5 |
| Molecular Weight | 352.4651 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 2 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCC[C@H](O)\C=C\[C@H]1O[C@H]2C[C@H](O2)[C@@H]1C\C=C/CCCC(O)=O
InChI
InChIKey=DSNBHJFQCNUKMA-SCKDECHMSA-N
InChI=1S/C20H32O5/c1-2-3-6-9-15(21)12-13-17-16(18-14-20(24-17)25-18)10-7-4-5-8-11-19(22)23/h4,7,12-13,15-18,20-21H,2-3,5-6,8-11,14H2,1H3,(H,22,23)/b7-4-,13-12+/t15-,16+,17+,18-,20+/m0/s1
| Molecular Formula | C20H32O5 |
| Molecular Weight | 352.4651 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 5 / 5 |
| E/Z Centers | 2 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of recombinant human superoxide dismutase on tumor necrosis factor-induced lung injury in awake sheep. | 1993 Jun |
|
| Maintained hyperexcretion of thromboxane A2 metabolite in healthy young cigarette smokers: results from a prospective study in randomly sampled males with stable smoking habits. | 1993 May |
|
| [Measurement of platelet thromboxane A2/prostaglandin H2 receptor in asthmatic patients]. | 1993 May |
|
| Increased platelet thromboxane A2/prostaglandin H2 receptors in patients with pregnancy induced hypertension. | 1993 May 1 |
|
| The effect of prostaglandins and thromboxane A2 on coronary vessel tone--mechanisms of action and therapeutic implications. | 1993 Nov |
|
| Platelet activation results in a redistribution of glycoprotein IV (CD36). | 1994 Jul |
|
| Increased number of thromboxane A2-prostaglandin H2 platelet receptors in active unstable angina and causative role of enhanced thrombin formation. | 1995 May |
|
| Heparin-protamine complexes cause pulmonary hypertension in goats. | 1995 Oct |
|
| Role of thromboxane A2, endothelin-1 and endothelin-3 in rat nephrotoxic serum nephritis. | 1996 Apr |
|
| Effect of antiestrogen regimen on prostacyclin and thromboxane A2 in postmenopausal patients with breast cancer: evidence of significance of hypertension, smoking or previous use of estrogen therapy. | 1996 Oct |
|
| Labeling of human platelet plasma membrane thromboxane A2/prostaglandin H2 receptors using SQB, a novel biotinylated receptor probe. | 1996 Sep 13 |
|
| Changes in platelet calcium concentration by thromboxane A2 stimulation in patients with nephrotic syndrome of childhood. | 1997 |
|
| Deficiency of (33P)2MeS-ADP binding sites on platelets with secretion defect, normal granule stores and normal thromboxane A2 production. Evidence that ADP potentiates platelet secretion independently of the formation of large platelet aggregates and thromboxane A2 production. | 1997 May |
|
| Fatty acids, triglycerides and syndromes of insulin resistance. | 1997 Oct |
|
| Identification of Galpha13 as one of the G-proteins that couple to human platelet thromboxane A2 receptors. | 1999 May 14 |
|
| The 5-HT2 receptor antagonist sarpogrelate reduces urinary and plasma levels of thromboxane A2 and urinary albumin excretion in non-insulin-dependent diabetes mellitus patients. | 1999 May-Jun |
|
| Inherited macrothrombocytopenia with distinctive platelet ultrastructural and functional features. | 2000 Jan |
|
| Increased 15-HPETE production decreases prostacyclin synthase activity during oxidant stress in aortic endothelial cells. | 2001 Feb 1 |
|
| A comparison of every-third-day versus daily low-dose aspirin therapy on serum thromboxane concentrations in healthy men and women. | 2001 Jan |
|
| The hyperaggregability of platelets from normal pregnancy is mediated through thromboxane A2 and cyclic AMP pathways. | 2002 Apr |
|
| Genetic variants of the receptors for thromboxane A2 and IL-4 in atopic dermatitis. | 2002 Apr 5 |
|
| Thromboxane synthase: structure and function of protein and gene. | 2002 Aug |
|
| Simultaneous changes in intracellular calcium and tension induced by endothelin-1 and sarafotoxin S6c in guinea pig isolated gallbladder: influence of indomethacin. | 2002 May |
|
| The role of chemical mediators in eosinophil infiltration in allergic rhinitis in mice. | 2003 Apr |
|
| Low-dose aspirin in pregnancy: maternal and neonatal aspirin concentrations and neonatal prostanoid formation. | 2003 Jan |
|
| Effects of hypoxia on monocyte inflammatory mediator production: Dissociation between changes in cyclooxygenase-2 expression and eicosanoid synthesis. | 2003 Oct 3 |
|
| Zileuton, a 5-lipoxygenase inhibitor, increases production of thromboxane A2 and platelet aggregation in patients with asthma. | 2003 Sep |
|
| Inhibitory effects of ligustrazine, a modulator of thromboxane-prostacycline-nitric oxide balance, on renal injury in rats with passive Heyman nephritis. | 2004 |
|
| Role of endothelin-1 and thromboxane A2 in the pulmonary hypertension induced by heparin-protamine interaction in anesthetized dogs. | 2004 Jan |
|
| Participation of chemical mediators in the development of experimental allergic conjunctivitis in rats. | 2004 Nov |
|
| Cyclo-oxygenase-2, endothelium and aortic reactivity during deoxycorticosterone acetate salt-induced hypertension. | 2005 May |
|
| Cyclooxygenase-1 haplotype modulates platelet response to aspirin. | 2005 Oct |
|
| Vasoactive prostanoids are generated from arachidonic acid by COX-1 and COX-2 in the mouse. | 2005 Oct |
|
| De novo synthesis of cyclooxygenase-1 counteracts the suppression of platelet thromboxane biosynthesis by aspirin. | 2006 Mar 17 |
|
| Imbalanced synthesis of cyclooxygenase-derived thromboxane A2 and prostacyclin compromises vasomotor function of the thoracic aorta in Marfan syndrome. | 2007 Oct |
|
| Thromboxane synthase mutations in an increased bone density disorder (Ghosal syndrome). | 2008 Mar |
|
| 1-Phenyl-6,7-dihydroxy-isochroman suppresses lipopolysaccharide-induced pro-inflammatory mediator production in human monocytes. | 2011 Jul |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 09:06:07 UTC 2023
by
admin
on
Sat Dec 16 09:06:07 UTC 2023
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| Record UNII |
4C2A5G825S
|
| Record Status |
Validated (UNII)
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| Record Version |
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-
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Common Name | English | ||
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| Classification Tree | Code System | Code | ||
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NCI_THESAURUS |
C879
Created by
admin on Sat Dec 16 09:06:08 UTC 2023 , Edited by admin on Sat Dec 16 09:06:08 UTC 2023
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| Code System | Code | Type | Description | ||
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57445
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DTXSID201317452
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57576-52-0
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15627
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5280497
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4C2A5G825S
Created by
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Thromboxane A2
Created by
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m10812
Created by
admin on Sat Dec 16 09:06:08 UTC 2023 , Edited by admin on Sat Dec 16 09:06:08 UTC 2023
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PRIMARY | Merck Index | ||
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C122988
Created by
admin on Sat Dec 16 09:06:08 UTC 2023 , Edited by admin on Sat Dec 16 09:06:08 UTC 2023
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PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
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TARGET -> AGONIST |
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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METABOLITE INACTIVE -> PARENT |
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PARENT -> METABOLITE ACTIVE |
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