LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A

Approval Year

Substance Class	Protein Created by `admin` on `Tue Apr 01 18:36:28 GMT 2025` Edited by `admin` on `Tue Apr 01 18:36:28 GMT 2025`
Protein Type	ENZYME
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	4APO0P2BE7
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A

Common Name

English

AOF2

Preferred Name

English

BRAF35-HDAC COMPLEX PROTEIN BHC110

Common Name

English

FLAVIN-CONTAINING AMINE OXIDASE DOMAIN-CONTAINING PROTEIN 2

Common Name

English

KIAA0601

Common Name

English

KDM1

Common Name

English

LSD1

Common Name

English

Code System Code Type Description

FDA UNII

4APO0P2BE7

Created by admin on Tue Apr 01 18:36:28 GMT 2025 , Edited by admin on Tue Apr 01 18:36:28 GMT 2025

PRIMARY

UNIPROT

O60341

Created by admin on Tue Apr 01 18:36:28 GMT 2025 , Edited by admin on Tue Apr 01 18:36:28 GMT 2025

PRIMARY

Related Record Type Details


					LZ82JLT4UP

VAFIDEMSTAT

INHIBITOR -> TARGET


					XC0UT08SNJ

rel-trans-4-Amino-N-[(1R,2S)-2-phenylcyclopropyl]cyclohexanemethanamine

INHIBITOR -> TARGET


					12XU6D9FLM

INCB-059872

INHIBITOR -> TARGET

Interaction Type:

IRREVERSIBLE INHIBITOR

Amount:


					87ZW2258VM

T-914

INHIBITOR -> TARGET

Amount:


					W6F4FRQ5QC

PULRODEMSTAT

INHIBITOR -> TARGET


					8J6Q7Z3DJS

T-914 F-18

RADIOLIGAND->TARGET

Amount:


					N9N6RK0CBN

TAK-418 FREE BASE

INHIBITOR -> TARGET


					7UKY4JVM4R

JBI-802 FREE BASE

INHIBITOR -> TARGET

Interaction Type:

PRECLINICAL

Qualification:

IC50

Amount:


					54T74394F8

IADADEMSTAT

INHIBITOR -> TARGET


					16XG8UE639

ARBORININE

INHIBITOR -> TARGET

Comments:

99.33% INHIBITION @ 0.4 MICROMOLAR

Amount:


					GT77Z6Y09Z

GSK-2879552

INHIBITOR -> TARGET

Interaction Type:

IRREVERSIBLE INHIBITOR

Qualification:

IC50

Amount:


					Y2T4ALDEAT

BOMEDEMSTAT

INHIBITOR -> TARGET

Structural Modifications

Modification Type	Location Site	Fragment Name	Fragment Approval
AMINO ACID SUBSTITUTION	[1_135]	TYROSINE O-PHOSPHATE	2R86C98KDX
AMINO ACID SUBSTITUTION	[1_126] [1_131] [1_137] [1_166] [1_849]	DEXFOSFOSERINE	VI4F0K069V
AMINO ACID SUBSTITUTION	[1_59] [1_104]	THREONINE PHOSPHATE	3L4WX7B1EI

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT	CHEMICAL