TOMOGLUMIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C24H38N2O4
Molecular Weight	418.5695
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)C1=CC(C)=C(C)C=C1

InChI

InChIKey=UPKUMLKWNJTSMG-UHFFFAOYSA-N

InChI=1S/C24H38N2O4/c1-5-7-9-15-26(16-10-8-6-2)24(30)21(13-14-22(27)28)25-23(29)20-12-11-18(3)19(4)17-20/h11-12,17,21H,5-10,13-16H2,1-4H3,(H,25,29)(H,27,28)

HIDE SMILES / InChI

Molecular Formula	C24H38N2O4
Molecular Weight	418.5695
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/2188254 | https://www.ncbi.nlm.nih.gov/pubmed/2474165 | https://www.ncbi.nlm.nih.gov/pubmed/1340060

Tomoglumide (CR 1392) is the glutaramic acid-derivative. It is a cholecystokinin (CCK) receptor antagonist. The CR 1392 had an inhibitory effect on both CCK-octapeptide (CCK-8)-stimulated immunoreactive insulin (IRI) release and exocrine secretion in the isolated perfused rat pancreas. The concentration of CR 1392 that caused half-maximal inhibition of CCK-8-stimulated IRI release was 300 times lower than that of exocrine secretion. CR 1392 was also effective in reducing the elevated serum amylase activity, pancreatic weight, and histologic alterations even when administered after the pancreatitis had been induced.

Approval Year

PubMed

Title	Date	PubMed
Comparative effects of CCK receptor antagonists on rat pancreatic secretion in vivo.	1989 Jan	2463767
Proglumide analogues CR 1409 and CR 1392 inhibit cholecystokinin-stimulated insulin release more potently than exocrine secretion from the isolated perfused rat pancreas.	1990 May	2188254

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:50:01 GMT 2023` Edited by `admin` on `Fri Dec 15 15:50:01 GMT 2023`
Record UNII	4AO61I7SLB
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TOMOGLUMIDE

Official Name

English

tomoglumide [INN]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29701