Details
Stereochemistry | RACEMIC |
Molecular Formula | C24H38N2O4 |
Molecular Weight | 418.5695 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCCCCN(CCCCC)C(=O)C(CCC(O)=O)NC(=O)C1=CC(C)=C(C)C=C1
InChI
InChIKey=UPKUMLKWNJTSMG-UHFFFAOYSA-N
InChI=1S/C24H38N2O4/c1-5-7-9-15-26(16-10-8-6-2)24(30)21(13-14-22(27)28)25-23(29)20-12-11-18(3)19(4)17-20/h11-12,17,21H,5-10,13-16H2,1-4H3,(H,25,29)(H,27,28)
Molecular Formula | C24H38N2O4 |
Molecular Weight | 418.5695 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Tomoglumide (CR 1392) is the glutaramic acid-derivative. It is a cholecystokinin (CCK) receptor antagonist. The CR 1392 had an inhibitory effect on both CCK-octapeptide (CCK-8)-stimulated immunoreactive insulin (IRI) release and exocrine secretion in the isolated perfused rat pancreas. The concentration of CR 1392 that caused half-maximal inhibition of CCK-8-stimulated IRI release was 300 times lower than that of exocrine secretion. CR 1392 was also effective in reducing the elevated serum amylase activity, pancreatic weight, and histologic alterations even when administered after the pancreatitis had been induced.
Approval Year
PubMed
Title | Date | PubMed |
---|---|---|
Comparative effects of CCK receptor antagonists on rat pancreatic secretion in vivo. | 1989 Jan |
|
Proglumide analogues CR 1409 and CR 1392 inhibit cholecystokinin-stimulated insulin release more potently than exocrine secretion from the isolated perfused rat pancreas. | 1990 May |
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:50:01 GMT 2023
by
admin
on
Fri Dec 15 15:50:01 GMT 2023
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Record UNII |
4AO61I7SLB
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Record Status |
Validated (UNII)
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Record Version |
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Common Name | English |
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NCI_THESAURUS |
C29701
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NCI_THESAURUS |
C28197
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5962
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97964-54-0
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65852
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100000077769
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C74180
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4AO61I7SLB
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CHEMBL2107668
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SUB11185MIG
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Related Record | Type | Details | ||
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ACTIVE MOIETY |