FERRIC PICOLINATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	3C6H4NO2.Fe
Molecular Weight	422.149
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[Fe+3].[O-]C(=O)C1=NC=CC=C1.[O-]C(=O)C2=NC=CC=C2.[O-]C(=O)C3=NC=CC=C3

InChI

InChIKey=XYLIUBFEJNAWSC-UHFFFAOYSA-K

InChI=1S/3C6H5NO2.Fe/c3*8-6(9)5-3-1-2-4-7-5;/h3*1-4H,(H,8,9);/q;;;+3/p-3

HIDE SMILES / InChI

Molecular Formula	Fe
Molecular Weight	55.845
Charge	3
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C6H4NO2
Molecular Weight	122.1015
Charge	-1
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/18284482

Ferric picolinate and ferric acetohydroxamate are effective anti-biofilm compounds against both lab and clinical strains of P. aeruginosa and are readily nebulized into particles of suitable size for lung delivery.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Pseudomonas aeruginosa 12 Target ID: CHEMBL348 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18284482	Inhibitor 8297		80.0 µM [IC50]

Conditions

Condition	Modality	Targets	Highest Phase	Product
Cystic fibrosis 120 Sources: https://www.ncbi.nlm.nih.gov/pubmed/18284482	Primary		Basic research	Unknown Approved Use Unknown

PubMed

Title	Date	PubMed
Iron(III)picolinate-induced oxygenation and subsequent rearrangement of triterpenoid derivatives with hydrogen peroxide.	2000 Jan	10705487
Chelated iron sources are inhibitors of Pseudomonas aeruginosa biofilms and distribute efficiently in an in vitro model of drug delivery to the human lung.	2008 Aug	18284482

Patents

Sample Use Guides

In Vivo Use Guide

Unknown

Route of Administration: Unknown

In Vitro Use Guide

Ferric picolinate (50-500 umol/l) inhibited Pseudomonas aeruginosa biofilms. As iron (Ferric picolinate) concentration increased, Pseudomonas aeruginosa biofilm increased from 0 to 50 umol/l, when the trend reversed and the biofilms of P. aeruginosa PA14 were powerfully disrupted, with IC50 80 umol/l.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 08:06:41 UTC 2023` Edited by `admin` on `Sat Dec 16 08:06:41 UTC 2023`
Record UNII	48VAK352CN
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

FERRIC PICOLINATE

Common Name

English

IRON, TRIS(2-PYRIDINECARBOXYLATO-.KAPPA.N1,.KAPPA.O2)-

Systematic Name

English

IRON(III) PICOLINATE

Systematic Name

English

Iron picolinate [WHO-DD]

Common Name

English

IRON PICOLINATE [INCI]

Common Name

English

IRON, TRIS(PICOLINATO)-

Common Name

English

IRON PICOLINATE

Official Name

English

Code System Code Type Description

EPA CompTox

DTXSID30725310