Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C11H15N5O3 |
| Molecular Weight | 265.2685 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CNC1=C2N=CN([C@H]3C[C@H](O)[C@@H](CO)O3)C2=NC=N1
InChI
InChIKey=DYSDOYRQWBDGQQ-XLPZGREQSA-N
InChI=1S/C11H15N5O3/c1-12-10-9-11(14-4-13-10)16(5-15-9)8-2-6(18)7(3-17)19-8/h4-8,17-18H,2-3H2,1H3,(H,12,13,14)/t6-,7+,8+/m0/s1
| Molecular Formula | C11H15N5O3 |
| Molecular Weight | 265.2685 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 3 / 3 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Purinergic receptors in the rat lens: activation of P2X receptors following hyperosmotic stress. | 2010-08 |
|
| Adenosine triphosphate stimulates RANKL expression through P2Y1 receptor-cyclo-oxygenase-dependent pathway in human periodontal ligament cells. | 2010-06 |
|
| P2Y1 receptors mediate apamin-sensitive and -insensitive inhibitory junction potentials in murine colonic circular smooth muscle. | 2010-05 |
|
| Two-pore potassium ion channels are inhibited by both G(q/11)- and G(i)-coupled P2Y receptors. | 2010-04 |
|
| Acetylsalicylic acid enhances purinergic receptor-mediated outward currents in rat megakaryocytes. | 2010-03 |
|
| Endogenous purinergic signaling is required for osmotic volume regulation of retinal glial cells. | 2010-03 |
|
| AMP N(1)-oxide, a unique compound of royal jelly, induces neurite outgrowth from PC12 cells via signaling by protein kinase A independent of that by mitogen-activated protein kinase. | 2010-03 |
|
| Axons and astrocytes release ATP and glutamate to evoke calcium signals in NG2-glia. | 2010-01-01 |
|
| CNGA2 contributes to ATP-induced noncapacitative Ca2+ influx in vascular endothelial cells. | 2010 |
|
| The P2Y(1) and P2Y(12) receptors mediate autoinhibition of transmitter release in sympathetic innervated tissues. | 2009-12 |
|
| Increase of intracellular Ca2+ by P2Y but not P2X receptors in cultured cortical multipolar neurons of the rat. | 2009-10-10 |
|
| Extracellular ADP regulates lesion-induced in vivo cell proliferation and death in the zebrafish retina. | 2009-10 |
|
| P2 receptor-mediated signaling in spherical bushy cells of the mammalian cochlear nucleus. | 2009-09 |
|
| Role of P2Y1 receptor in astroglia-to-neuron signaling at dorsal spinal cord. | 2009-09 |
|
| Role of purinergic P2Y1 receptors in regulation of vasopressin and oxytocin secretion. | 2009-08 |
|
| Electrical stimulation of the mucosa evokes slow EPSPs mediated by NK1 tachykinin receptors and by P2Y1 purinoceptors in different myenteric neurons. | 2009-07 |
|
| The NANC relaxation of the human ileal longitudinal and circular muscles is inhibited by MRS 2179, a P2 purinoceptor antagonist. | 2009-06-19 |
|
| Mechanism of activation and functional role of protein kinase Ceta in human platelets. | 2009-05-15 |
|
| Investigation of the role of adrenergic and non-nitrergic, non-adrenergic neurotransmission in the sheep isolated internal anal sphincter. | 2009-03 |
|
| Platelet responsiveness to yohimbine hydrochloride and MRS2179 in the context of the interaction between collagen and epinephrine in acute coronary syndrome. | 2009-01-16 |
|
| P2Y1 receptor activation elicits its partition out of membrane rafts and its rapid internalization from human blood vessels: implications for receptor signaling. | 2008-12 |
|
| Ca2+ signaling in injured in situ endothelium of rat aorta. | 2008-09 |
|
| Effects of P2Y1 receptor on glial fibrillary acidic protein and glial cell line-derived neurotrophic factor production of astrocytes under ischemic condition and the related signaling pathways. | 2008-08 |
|
| GPR17: molecular modeling and dynamics studies of the 3-D structure and purinergic ligand binding features in comparison with P2Y receptors. | 2008-06-04 |
|
| Contribution of P2Y(1) receptors to ADP signalling in mouse spinal cord cultures. | 2008-04-25 |
|
| Functional evidence for purinergic inhibitory neuromuscular transmission in the mouse internal anal sphincter. | 2008-04 |
|
| Acyl derivatives of coenzyme A inhibit platelet function via antagonism at P2Y1 and P2Y12 receptors: a new finding that may influence the design of anti-thrombotic agents. | 2008-03 |
|
| Involvement of P2Y1 and P2Y11 purinoceptors in parasympathetic inhibition of colonic smooth muscle. | 2008-03 |
|
| P2Y1 receptors mediate inhibitory neuromuscular transmission and enteric neuronal activation in small intestine. | 2008-02 |
|
| Possible role of extracellular nucleotides in ectopic ossification of human spinal ligaments. | 2008-01 |
|
| Gi-coupled P2Y-ADP receptor mediates GSK-3 phosphorylation and beta-catenin nuclear translocation in granule neurons. | 2008-01 |
|
| Inhibition of ATP-induced glutamate release by MRS2179 in cultured dorsal spinal cord astrocytes. | 2008 |
|
| Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells. | 2007-12-15 |
|
| Pulses of somatostatin release are slightly delayed compared with insulin and antisynchronous to glucagon. | 2007-12-04 |
|
| P2Y receptor-activating nucleotides modulate cellular reactive oxygen species production in dissociated hippocampal astrocytes and neurons in culture independent of parallel cytosolic Ca(2+) rise and change in mitochondrial potential. | 2007-11-15 |
|
| The ADP receptor P2Y(1) mediates t-PA release in pigs during cardiac ischemia. | 2007-10 |
|
| Reference curves for aggregation and ATP secretion to aid diagnose of platelet-based bleeding disorders: effect of inhibition of ADP and thromboxane A(2) pathways. | 2007-08 |
|
| ATP release and hydrolysis contribute to rat pial arteriolar dilatation elicited by neuronal activation. | 2007-07 |
|
| Inhibitory neuromuscular transmission mediated by the P2Y1 purinergic receptor in guinea pig small intestine. | 2007-06 |
|
| Evidence that ATP or a related purine is an excitatory neurotransmitter in the longitudinal muscle of mouse distal colon. | 2007-05 |
|
| Glycoprotein Ibalpha inhibition and ADP receptor antagonists, but not aspirin, reduce platelet thrombus formation in flowing blood exposed to atherosclerotic plaques. | 2007-03 |
|
| A novel mechanism of vasoregulation: ADP-induced relaxation of the porcine isolated coronary artery is mediated via adenosine release. | 2007-02 |
|
| Stimulation of adenosine A1 and A2A receptors by AMP in the submucosal plexus of guinea pig small intestine. | 2007-02 |
|
| P2Y1 receptor modulation of the pre-Bötzinger complex inspiratory rhythm generating network in vitro. | 2007-01-31 |
|
| ATP increases intracellular calcium in supraoptic neurons by activation of both P2X and P2Y purinergic receptors. | 2007-01 |
|
| Mitochondrial calcium transport is regulated by P2Y1- and P2Y2-like mitochondrial receptors. | 2006-11-01 |
|
| Regulation of death and survival in astrocytes by ADP activating P2Y1 and P2Y12 receptors. | 2006-10-16 |
|
| Enhanced food intake after stimulation of hypothalamic P2Y1 receptors in rats: modulation of feeding behaviour by extracellular nucleotides. | 2006-10 |
|
| PAR4, but not PAR1, signals human platelet aggregation via Ca2+ mobilization and synergistic P2Y12 receptor activation. | 2006-09-08 |
|
| P2Y receptor-mediated excitation in the posterior hypothalamus. | 2006-09 |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 18:43:08 GMT 2025
by
admin
on
Mon Mar 31 18:43:08 GMT 2025
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| Record UNII |
48QZW2IR9H
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| Record Status |
Validated (UNII)
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| Record Version |
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66392
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48QZW2IR9H
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168948
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2002-35-9
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DTXSID60173840
Created by
admin on Mon Mar 31 18:43:08 GMT 2025 , Edited by admin on Mon Mar 31 18:43:08 GMT 2025
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PRIMARY |